Klin Monbl Augenheilkd 1991; 198(5): 340-343
DOI: 10.1055/s-2008-1045975
© 1991 F. Enke Verlag Stuttgart

Comparaison de l'effet antimiotique du flurbiprophène 0.03% par rapport à l'indomethacine 1% pendant l'extraction extracapsulaire de la cataracte

Comparison of the Antimiotic Effect of Flurbiprofen 0,03% and Indomethacin 1% during Extracapsular Cataract ExtractionM. Vignanelli, C. A. Stucchi, D. Beati, G. Ortelli, G. Gennari
  • Reparto Oftalmologia, Ospedale Civico, Lugano (Primario: Dott. Med. C. A. Stucchi, PD)
Further Information

Publication History

Publication Date:
11 February 2008 (online)

Vergleich der antimiotischen Wirkung von Flurbiprophen 0,03% mit Indomethacin 1% während extrakapsulärer Linsenextraktion

Es wurde eine prospektive Doppelblindstudie zum Vergleich der antimiotischen Wirkung von Flurbiprophen 0,03% und Indomethacin 1% durchgeführt. Bei 40 Patienten wurde während des Eingriffs mehrfach der Pupillendurchmesser vertikal und horizontal aufgezeichnet. Die Pupillenverkleinerung nach Kernextraktion betrug bei mit Indomethacin behandelten Patienten im Mittel 1,54 mm, bei mit Flurbiprophen behandelten Patienten durchschnittlich 1,28 mm. Nach Absaugen der kortikalen Masse betrug bei der Indomethacin-Gruppe der Pupillendurchmesser 2,28 mm, bei der Flurbiprophen-Gruppe 2,00 mm. Obwohl die Unterschiede zwischen diesen Werten statistisch nicht signifikant sind, wurde gezeigt, dass Flurbiprophen 0,03% nach einem chirurgischen Eingriff eine etwas stärkere antimiotische Wirkung aufweist.

Summary

Maintaining successful mydriasis is essential during cataract extraction. The use of nonsteroidal anti-inflammatory drugs in order to inhibit trauma induced miosis has been advocated by many authors. Indomethacin 1% has proved his efficacy since many years. Flurbiprofen has been introduced more recently and has been accepted largely because of a better patient comfort. He proved his efficacy against placebo. We conducted a randomized doubble blind study in order to verify if there is any difference in efficacy between these two drugs. 40 cases were randomly assigned to a pre-treatment, not known by the surgeons, with Indomethacin 1% (Indoptic®) or Flurbiprofen 0,03% (Ocuflur®). Measurements were taken at the beginning of surgery, after nucleous extraction and after irrigationaspiration of lens cortical material. Sodium hyaluronate and epinephrine were not used during this study. After nucleous extraction, the mean pupillary constriction was 1,53 mm in the Indomethacin group and 1,23 mm in the Flurbiprofen group (p>0,l). After aspiration of cortical material, the mean pupillary constriction was 2,27 mm in the Indomethacin group and 2,00 in the Flurbiprofen group (p>0,l). Cumulative results of patients who constricted the pupil more than 2 and 3 mm showed a better result in the Flurbiprofen group. Flurbiprofen has proved in this study his efficacy compared to an other nonsteroidal anti-inflammatory drug in inhibiting trauma induced miosis.