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Synfacts 2008(1): 0059-0059  
DOI: 10.1055/s-2007-991430
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Novel La/Trifloroacetic Anhydride Catalyzed Nucleophilic Addition

Contributor(s): Hisashi Yamamoto, Marina Naodovic
W. W. Ong, A. B. Beeler, S. Kesavan, J. S. Panek, J. A. Porco, Jr.*
Boston University, USA
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Porco’s group has developed an efficient method for addition of various carbon nucleophiles to phosphinylimines. The generation of unexpected trifluoroacetamide products indicates novel mechanistic details for the lanthanum/tri­fluoroacetic anhydride mediated addition reaction.