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Synfacts 2008(1): 0051-0051
DOI: 10.1055/s-2007-991425
DOI: 10.1055/s-2007-991425
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
DKR: Synthesis of cis-α-Aminocycloalkanols by Ruthenium-Catalyzed Hydrogenation
S. Liu, J.-H. Xie, L.-X. Wang, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
Further Information
Publication History
Publication Date:
18 December 2007 (online)
Significance
Dynamic kinetic resolution (DKR) is a useful method for the synthesis of enantioenriched materials. The Zhou group has utilized DKR for the synthesis of α-aminocycloalkanols via a ruthenium-catalyzed hydrogenation reaction. A very wide variety of cyclic α-aminoketones were successful in this reaction. Hydrogen was used at a pressure of 10 atm.