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Synfacts 2007(1): 0053-0053  
DOI: 10.1055/s-2006-955714
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Enantioselective Conjugate Reduction of Enones

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
Y. Tsuchiya, Y. Hamashima, M. Sodeoka*
RIKEN, Wako, Japan
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Publikationsverlauf

Publikationsdatum:
15. Dezember 2006 (online)

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Significance

Several methods exist for asymmetric reduction of β,β-disubstituted enones, however, to date all known methods require more than stoichiometric amounts of reducing agents. This paper describes the utilization of environmentally friendly EtOH as a hydride source.