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Synfacts 2006(7): 0641-0641  
DOI: 10.1055/s-2006-941831
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Flustramine B and(-)-Flustramide B

Contributor(s): Philip Kocienski, Fiona Black
T. Kawasaki*, M. Shinada, D. Kamimura, M. Ohzono, A. Ogawa
Meiji Pharmaceutical University, Tokyo, Japan
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

The installation of the quaternary carbon stereocenter using an olefination-isomerization-Claisen rearrangement cascade is a key feature of the depicted synthesis. The hexahydropyrrolo[2,3-b]indole core is constructed via a chemoselective reductive cyclization.