Synthesis of Strobilurin B

R. S. Coleman; X. Lu

doi:10.1055/s-2006-941824

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Synfacts 2006(7): 0638-0638
DOI: 10.1055/s-2006-941824

Synthesis of Natural Products and Potential Drugs

Synthesis of Strobilurin B

Contributor(s): Philip Kocienski, John Cooksey
R. S. Coleman*, X. Lu
The Ohio State University, Columbus, USA

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Publication History

Publication Date:
22 June 2006 (online)

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Significance

Strobilurin B is a potent anti-fungal agent. Coleman and Lu report a short, stereocontrolled total synthesis of Strobilurin B using two Pd-catalyzed cross-couplings of a hetero-bis-metallated pentadiene system.