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Synfacts 2006(6): 0584-0584  
DOI: 10.1055/s-2006-934477
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd(II)-Catalyzed Enantioselective Synthesis of Indolines

Contributor(s): Mark Lautens, Andrew Martins
K.-T. Yip, M. Yang, K.-L. Law, N.-Y. Zhu, D. Yang*
The University of Hong Kong, P. R. of China
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Publikationsverlauf

Publikationsdatum:
19. Mai 2006 (online)

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Significance

Using oxidative tandem palla­dium(II) catalysis, a variety of aniline-based bis-alkenes were converted into the corresponding indolines in good yields. When (-)-sparteine was used as ligand, good to very good enantiomeric excesses were obtained, generating up to two new stereogenic centers in one step.