Pharmacopsychiatry 2005; 38(2): 98-100
DOI: 10.1055/s-2005-837811
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Little Effects of Low Dosage of Levomepromazine on Plasma Risperidone Levels

R. Yoshimura1 , K. Shinkai1 , S. Kakihara1 , M. Goto1 , Y. Yamada1 , K. Kaji1 , N. Ueda1 , J. Nakamura1
  • 1Department of Psychiatry, University of Occupational and Environmental Health, Japan
Further Information

Publication History

Received: 14.6.2004 Revised: 15.6.2004

Accepted: 21.7.2004

Publication Date:
02 March 2005 (online)

In the present study, we investigated the effects of levomepromazine on plasma risperidone concentrations in a steady state. Twenty patients taking risperidone at a stable dose for more than 2 weeks who were considered to require levomepromazine coadministration were selected. The scores of excitement in BPRS significantly decreased 2 weeks after the coadministration of levomepromazine. Plasma risperidone concentrations and the ratio of risperidone and 9-hydroxyrisperidone (risperidone/9-hydroxyrisperidone) did not change between before and 2 weeks after the coadministration of levomepromazine. The extrapyramidal symptoms were not worsened by the coadministration of levomepromazine. These results suggest that a low dosage of levomepromazine, use as a sedative adjuvant to risperidone treatment, have no statistically significant effect on the trough plasma concentrations of risperidone.

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Dr. Reiji Yoshimura

Department of Psychiatry

University of Occupational and Environmental Health

Iseigaoka

Yahatanishi-ku

Kitakyushu

Fukuoka 807-8555

Japan

Phone: +81 936 917253

Fax: +81 936 924894

Email: yoshi621@med.uoeh-u.ac.jp