Solvent-Free Synthesis of Chiral N,N′-Disubstituted Thioureas by ‘Just Mixing’ the Reagents

Jaime Vázquez; Sylvain Bernès; Yasmi Reyes; Mónica Moya; Pankaj Sharma; Cecilio Alvarez; René Gutiérrez

doi:10.1055/s-2004-829167

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Synthesis 2004(12): 1955-1958
DOI: 10.1055/s-2004-829167

PAPER

Solvent-Free Synthesis of Chiral N,N′-Disubstituted Thioureas by ‘Just Mixing’ the Reagents

Jaime Vázquez^a, Sylvain Bernès^b, Yasmi Reyes^b, Mónica Moya^c, Pankaj Sharma^c, Cecilio Alvarez^c, René Gutiérrez*^a
^a Laboratorio de Síntesis de Complejos, Facultad de Ciencias Químicas, Universidad Autónoma de Puebla, A.P. 1067, 72001 Puebla, Pue., México
^b Centro de Química, Instituto de Ciencias, Universidad Autónoma de Puebla, A.P. 1613, 72000 Puebla, Pue., México
^c Instituto de Química-UNAM, Circuito exterior, Ciudad Universitaria, Coyoacán, C.P. 04510, México, D.F.
Fax: +52(222)2454972; e-Mail: jrgutie@siu.buap.mx;

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Publication History

Received 23 February 2004
Publication Date:
27 July 2004 (online)

Abstract
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Abstract

The synthesis of new chiral thioureas 3a-f by using the ecofriendly solvent-free and microwave-assisted approaches is reported and, unexpectedly, in the former method by just mixing the starting materials the products are instantaneously obtained. The crystal structures for 3b, 3c and 3e are also reported.

Key words

chiral thioureas - green-chemistry - crystallographic analysis

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