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Semin Respir Crit Care Med 2000; 21(6): 467-476
DOI: 10.1055/s-2000-13190
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Hereditary and Acquired Thrombophilia

Ivan Bank, Saskia Middeldorp, Harry R. Büller
  • Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

During the past decade knowledge about the etiology of venous thromboembolism has increased tremendously. Inherited and acquired risk factors for venous thromboembolism are common in patients as well as in the general population. Whether the presence of most of these risk factors has consequences for the management of symptomatic and asymptomatic individuals is not fully clear at present. Therefore, while searching for new thrombophilic defects, it is crucial to determine the absolute risk for (recurrent) venous thromboembolism as well as other clinical manifestations in carriers. However, tentative guidelines for managing patients and their families are given in this review.

KEYWORD

Thrombophilia - venous thromboembolism - risk factors - etiology - epidemiology

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