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Semin Respir Crit Care Med 2024; 45(01): 128-140
DOI: 10.1055/s-0043-1777267
Review Article

Pulmonary Aspergillosis in People with Cystic Fibrosis

C. Schwarz
1   HMU-Health and Medical University, Potsdam, Germany
2   Division Cystic Fibrosis, Clinic Westbrandenburg, Potsdam, Germany
,
P.N. Eschenhagen
1   HMU-Health and Medical University, Potsdam, Germany
2   Division Cystic Fibrosis, Clinic Westbrandenburg, Potsdam, Germany
,
J.G. Mainz
3   Department of Paediatric Pneumology, Allergology, Cystic Fibrosis Center, Klinikum Westbrandenburg, Brandenburg a. d. Havel, Germany
4   University Hospital of the Brandenburg Medical School, Brandenburg a. d. Havel, Germany
,
T. Schmidergall
1   HMU-Health and Medical University, Potsdam, Germany
2   Division Cystic Fibrosis, Clinic Westbrandenburg, Potsdam, Germany
,
H. Schuette
5   Pneumology and Respiratory Medicine, Ernst von Bergmann Klinikum, Potsdam, Germany
,
E. Romanowska
1   HMU-Health and Medical University, Potsdam, Germany
2   Division Cystic Fibrosis, Clinic Westbrandenburg, Potsdam, Germany
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Abstract

In the last decade, fungal respiratory diseases have been increasingly investigated for their impact on the clinical course of people with cystic fibrosis (CF), with a particular focus on infections caused by Aspergillus spp. The most common organisms from this genus detected from respiratory cultures are Aspergillus fumigatus and Aspergillus terreus, followed by Aspergillus flavus, Aspergillus niger, and Aspergillus nidulans. These species have been identified to be both chronic colonizers and sources of active infection and may negatively impact lung function in people with CF. This review article discusses definitions of aspergillosis, challenges in clinical practice, and current literature available for laboratory findings, clinical diagnosis, and treatment options for pulmonary diseases caused by Aspergillus spp. in people with CF.

Keywords

cystic fibrosis - Aspergillus respiratory infections - Aspergillus diagnostic - Aspergillus susceptibility testing - antifungals


Publication History

Article published online:
29 January 2024

© 2024. Thieme. All rights reserved.

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