Abstract
Functionalized xanthenes occupy an important position in medicinal chemistry due to
their wide range of pharmacological properties. The xanthene skeleton is present in
various bioactive natural products such as mulgravanols A and B, hermannol, (+)-myrtucommulone
D, homapanicones A and B, blumeaxanthene II, acrotrione, etc. Important xanthene-based
drugs, including propantheline bromide, methantheline, phloxine B, etc., are available
on the market. Thus, much effort has been dedicated to generating or modifying xanthenes
as crucial O -heterocyclic compounds. Recently, the development of efficient processes for the
synthesis of xanthene derivatives using modern techniques has received significant
attention in an effort to overcome the disadvantages of traditional methodologies.
Aligned with the sixth principle of green chemistry, in which minimum energy is needed
to perform synthetic methods at ambient temperature with optimum productivity, this
account focuses on green, room-temperature strategies for the synthesis of xanthenes
with anticancer activities using modern synthetic methodologies.
1 Introduction
2 Synthesis of Functionalized Xanthene Derivatives through Green Strategies at Room
Temperature
3 Medicinal Perspectives on Functionalized Xanthene Derivatives as Anticancer Agents
4 Conclusion
5 List of Abbreviations
Key words bioactive
O -heterocycles - functionalized xanthenes - ambient conditions - anticancer agents
- sustainable chemistry - medicinal impact
