Laryngorhinootologie 2018; 97(05): 344-356
DOI: 10.1055/s-0043-124025
CME-Fortbildung
© Georg Thieme Verlag KG Stuttgart · New York

Beurteilung der chemosensorischen Funktion mit validierten Riech- und Schmecktests

Assessment of olfactory and gustatory function with validated tests
Önder Göktas
,
Susann Fräßdorf
,
Ute Walliczek-Dworschak
,
Pengfei Han
,
Thomas Hummel
Further Information

Publication History

Publication Date:
02 May 2018 (online)

Zusammenfassung

Etwa 5 % der Bevölkerung leiden unter einer funktionellen Anosmie, bei weiteren 15 % ist die Riechfunktion eingeschränkt. Ein Grundpfeiler der Behandlung durch den HNO-Arzt ist die Beurteilung der chemosensorischen Funktion durch psychophysische Riech- und Schmecktests. Die Verwendung standardisierter validierter Instrumente ist zwingend erforderlich, um Patienten nach dem neuesten wissenschaftlichen Stand über Therapieverfahren beraten zu können.

Abstract

Approximately 5 % of the general population is affected by functional anosmia. An additional 15 % exhibit decreased olfactory function. Many of these individuals ask ENT-doctors or neurologists for help. A cornerstone of the counselling process is the assessment of olfactory function. The aim of this work is to give a differentiated overview about the administration of commonly used psychophysical tests for olfactory and gustatory function including their normative data. The use of standardized, reliable and validated tools is mandatory to provide patients with state-of the-art counseling on treatment options.

 
  • Literatur

  • 1 Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004; 114: 1764-1769
  • 2 Murphy C, Schubert CR, Cruickshanks KJ. et al. Prevalence of olfactory impairment in older adults. JAMA 2002; 288: 2307-2312
  • 3 Hummel T, Kobal G, Gudziol H. et al. Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 2007; 264: 237-243
  • 4 Doty RL, Shaman P, Applebaum SL. et al. Smell identification ability: changes with age. Science 1984; 226: 1441-1443
  • 5 Mackay-Sim A, Johnston AN, Owen C. et al. Olfactory ability in the healthy population: Reassessing presbyosmia. Chem Senses 2006; 31: 763-771
  • 6 Almkvist O, Berglund B, Nordin S. Odor detectability in successfully aged elderly and young adults. Reports from the Dept of Psychology, Stockholm University 1992; 744: 1-12
  • 7 Temmel AF, Quint C, Schickinger-Fischer B. et al. Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 2002; 128: 635-641
  • 8 Leopold DA, Bartels S. Evaluation of olfaction. J Otolaryngol 2002; 31 (Suppl. 01) 18-23
  • 9 Damm M, Temmel A, Welge-Lussen A. et al. [Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland]. HNO 2004; 52: 112-120
  • 10 Beule AG. [Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities and economic burden]. Laryngorhinootologie 2015; 94 (Suppl. 01) 1-23
  • 11 Croy I, Nordin S, Hummel T. Olfactory disorders and quality of life – an updated review. Chem Senses 2014; 39: 185-194
  • 12 Santos DV, Reiter ER, DiNardo LJ. et al. Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg 2004; 130: 317-319
  • 13 Murphy C, Cain WS, Bartoshuk LM. Mutual action of taste and olfaction. Sens Processes 1977; 1: 204-211
  • 14 Landis BN, Hummel T, Hugentobler M. et al. Ratings of overall olfactory function. Chem Senses 2003; 28: 691-694
  • 15 Soter A, Kim J, Jackman A. et al. Accuracy of self-report in detecting taste dysfunction. Laryngoscope 2008; 118: 611-617
  • 16 Delank KW, Fechner G. Zur Pathophysiologie der posttraumatischen Riechstörungen. Laryngol Rhinol Otol 1996; 75: 154-159
  • 17 Lötsch J, Reither N, Bogdanov V. et al. A brain-lesion pattern based algorithm for the diagnosis of post-traumatic olfactory loss. Rhinology 2015; 53 (04) 365-370
  • 18 Damm M, Leung RM, Kern RC. Sinonasal olfactory disorders. In: Welge-Luessen A, Hummel T. eds. Management of smell and taste disorders. Stuttgart: Thieme; 2014: 76-90
  • 19 Gudziol V, Buschhuter D, Abolmaali N. et al. Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis – a longitudinal study. Brain 2009; 132: 3096101
  • 20 Kobal G. Elektrophysiologische Untersuchungen des menschlichen Geruchssinns. Stuttgart: Thieme; 1981
  • 21 Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984; 32: 489-502
  • 22 Cain WS. Testing olfaction in a clinical setting. Ear Nose Throat J 1989; 68: 321-328
  • 23 Kondo H, Matsuda T, Hashiba M. et al. A study of the relationship between the T&T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol 1998; 12: 353-358
  • 24 Kobal G, Hummel T, Sekinger B. et al. “Sniffin’ Sticks”: Screening of olfactory performance. Rhinology 1996; 34: 222-226
  • 25 Hummel T, Sekinger B, Wolf SR. et al. ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 1997; 22: 39-52
  • 26 Hedner M, Larsson M, Arnold N. et al. Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol 2010; 30: 1-6
  • 27 Lotsch J, Reichmann H, Hummel T. Different odor tests contribute differently to the evaluation of olfactory loss. Chem Senses 2008; 33: 17-21
  • 28 Doty RL, Smith R, McKeown DA. et al. Tests of human olfactory function: principle component analysis suggests that most measure a common source of variance. Percept Psychophys 1994; 56: 701-707
  • 29 Frasnelli J, Livermore A, Soiffer A. et al. Comparison of lateralized and binasal olfactory thresholds. Rhinology 2002; 40: 129-134
  • 30 Sorokowska A, Albrecht E, Hummel T. Reading first or smelling first? Effects of presentation order on odor identification. Atten Percept Psychophys 2015; 77: 731-736
  • 31 Sorokowska A, Albrecht E, Haehner A. et al. Extended version of the ‘‘Sniffin’ Sticks’’ identification test: test-retest reliability and validity. J Neurosci Methods 2015; 243: 111-114
  • 32 Haehner A, Mayer AM, Landis BN. et al. High test-retest reliability of the extended version of the “Sniffin’ Sticks” test. Chem Senses 2009; 34: 705-711
  • 33 Schriever VA, Góis-Eanes M, Schuster B. et al. Olfactory event-related potentials in infants. J Pediatr 2014; 165: 372-375
  • 34 Doty RL, McKeown DA, Lee WW. et al. A study of the testretest reliability of ten olfactory tests. Chem Senses 1995; 20: 64556
  • 35 Hugh SC, Siu J, Hummel T. et al. Comparison of Sniffin’ Sticks and University of Pennsylvania Smell Identification Test (UPSIT). J Otolaryngol HNS 2015; 44: 10
  • 36 Doty RL, Cameron EL. Sex differences and reproductive hormone influences on human odor perception. Physiol Behav 2009; 97: 21328
  • 37 Frasnelli J, Hummel T. Olfactory dysfunction and daily life. Eur Arch Otorhinolaryngol 2005; 262: 231-235
  • 38 Kobal GKL, Wolfensberger M, Gudziol H. et al. Multicenter investigation of 1036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 2000; 257: 205-211
  • 39 Wolfensberger M, Schnieper I, Welge-Lussen A. “Sniffin’ Sticks”: a new olfactory test battery. Acta Otolaryngol 2000; 120: 303-306
  • 40 Aschenbrenner K, Hummel C, Teszmer K. et al. The influence of olfactory loss on dietary behaviors. Laryngoscope 2008; 118: 13544
  • 41 Koskinen S, Nenonen A, Tuorila H. Intakes of cold cuts in the elderly are predicted by olfaction and mood, but not by flavor type or intensity of the products. Physiol Behav 2005; 85: 314-323
  • 42 Gudziol V, Wolff-Stephan S, Aschenbrenner K. et al. Depression resulting from olfactory dysfunction is associated with reduced sexual appetite – a cross-sectional cohort study. J Sex Med 2009; 6: 1924-1929
  • 43 Croy I, Negoias S, Novakova L. et al. Learning about the functions of the olfactory system from people without a sense of smell. PLoS One 2012; 7: e33365
  • 44 Burdach KJ, Kroeze JH, Koster EP. Nasal, retronasal, and gustatory perception: an experimental comparison. Percept Psychophys 1984; 36: 205-208
  • 45 Duffy VB, Cain WS, Ferris AM. Measurement of sensitivity to olfactory flavor: application in a study of aging and dentures. Chem Senses 1999; 24: 671-677
  • 46 Landis BN, Hummel T, Lacroix JS. Basic and clinical aspects of olfaction. Adv Tech Stand Neurosurg 2005; 30: 69-105
  • 47 Burdach KJ, Doty RL. The effects of mouth movements, swallowing, and spitting on retronasal odor perception. Physiol Behav 1987; 41: 353-356
  • 48 Pfaar O, Landis BN, Frasnelli J. et al. Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions. Chem Senses 2006; 31: 27-31
  • 49 Heilmann S, Strehle G, Rosenheim K. et al. Clinical assessment of retronasal olfactory function. Arch Otorhinolaryngol Head Neck Surg 2002; 128: 414-418
  • 50 Konstantinidis I, Triaridis S, Triaridis A. et al. How do children with adenoid hypertrophy smell and taste? Clinical assessment of olfactory function pre- and post-adenoidectomy. Int J Pediatr Otorhinolaryngol 2005; 69: 1343-1349
  • 51 Gagnon L, Ismaili AR, Ptito M. et al. Superior orthonasal but not retronasal olfactory skills in congenital blindness. PLoS One 2015; 10 (03) e0122567
  • 52 Renner B, Mueller CA, Dreier J. et al. The candy smell test: a new test for retronasal olfactory performance. Laryngoscope 2009; 119: 487-495
  • 53 Khil L, Wellmann J, Berger K. Determinants of Single and Multiple Sensory Impairments in an Urban Population. Otolaryngol Head Neck Surg 2015; 153: 364-371
  • 54 Welge-Lussen A, Dorig P, Wolfensberger M. et al. A study about the frequency of taste disorders. J Neurol 2011; 258: 386-392
  • 55 Gudziol H, Hummel T. Normative values for the assessment of gustatory function using liquid tastants. Acta Otolaryngol 2007; 127: 658-661
  • 56 Welge-Luessen A, Leopold DA, Miwa T. Smell and Taste Disorders – Diagnostic and Clinical Work-Up. In: Welge-Luessen A, Hummel T. eds. Management of Smell and Taste Disorders – A Practical Guide for Clinicians. Stuttgart: Thieme; 2013: 49-57
  • 57 Mueller CA, Pintscher K, Renner B. Clinical test of gustatory function including umami taste. Ann Otol Rhinol Laryngol 2011; 120: 358-362
  • 58 Landis BN, Welge-Luessen A, Brämerson A. et al. Normative values for the assessment of gustatory function using impregnated filter papers (“Taste Strips”). Arch ORL 2008; 256: 242-248
  • 59 Stillman JA, Morton RP, Hay KD. et al. Electrogustometry: strengths, weaknesses, and clinical evidence of stimulus boundaries. Clin Otolaryngol Allied Sci 2003; 28: 406-410
  • 60 Croy I, Lange K, Krone F. et al. Comparison between odor thresholds for phenyl ethyl alcohol and butanol. Chem Senses 2009; 34: 523-527
  • 61 Ehrenstein WH, Ehrenstein A. Psychophysical methods. In: Windhorst U, Johansson H. eds. Modern techniques in neuroscience research. Berlin: Springer; 1999: 1211-1241
  • 62 Sorokowska A, Schriever VA, Gudziol V. et al. Changes of olfactory abilities in relation to age: odor identification in more than 1400 people aged 4 to 80 years. Eur Arch Otorhinolaryngol 2015; 272: 1937-1944
  • 63 Shu CH, Yuan BC, Lin SH. et al. Cross-cultural application of the “Sniffin’ Sticks” odor identification test. Am J Rhinol 2007; 21: 570-573
  • 64 Konstantinidis I, Printza A, Genetzaki S. et al. Cultural adaptation of an olfactory identification test: the Greek version of Sniffin’ Sticks. Rhinology 2008; 46: 292-296
  • 65 Richardson JT, Zucco GM. Cognition and olfaction: a review. Psychol Bull 1989; 105: 352-360
  • 66 Gudziol V, Hummel T. The influence of distractors on odor identification. Arch Otolaryngol Head Neck Surg 2009; 135: 143-145
  • 67 Negoias S, Troeger C, Rombaux P. et al. Number of descriptors in cued odor identification tests. Arch Otolaryngol Head Neck Surg 2010; 136: 296-300
  • 68 Welge-Luessen A, Temmel A, Quint C. et al. Olfactory function in patients with olfactory groove meningioma. J Neurol Neurosurg Psych 2001; 70: 218-221
  • 69 Negoias S, Friedrich H, Caversaccio MD. et al. Rapidly fluctuating anosmia: A clinical sign for unilateral smell impairment. Laryngoscope 2016; 126 (02) E57-E59
  • 70 Gudziol V, Lotsch J, Hahner A. et al. Clinical significance of results from olfactory testing. Laryngoscope 2006; 116: 1858-1863
  • 71 Hummel C, Zucco GM, Iannilli E. et al. OLAF: standardization of international olfactory tests. Eur Arch Otorhinolaryngol 2012; 269: 871-880
  • 72 Haxel BR, Bertz-Duffy S, Faldum A. et al. The Candy Smell Test in clinical routine. Am J Rhinol Allergy 2011; 25: e145-e148
  • 73 Mueller CA, Pintscher K, Renner B. Clinical test of gustatory function including umami taste. Ann Otol Rhinol Laryngol 2011; 120: 358-362
  • 74 Manzi B, Hummel T. Intensity of regionally applied tastes in relation to administration method: an investigation based on the ‘‘taste strips’’ test. Eur Arch Otorhinolaryngol 2014; 271: 411-415
  • 75 Mueller C, Renner B. A new procedure for the short screening of olfactory function using five items from the “Sniffin’ Sticks” identification test kit. Am J Rhinol 2006; 20: 113-116
  • 76 Freiherr J, Gordon AR, Alden EC. et al. The 40-item Monell Extended Sniffin’ Sticks Identification Test (MONEX-40). J Neurosci Methods 2012; 205: 10-16
  • 77 Schriever VA, Mori E, Petters W. et al. The ‘‘Sniffin’ Kids’’ Test – A 14-Item Odor Identification Test for Children. PLoS ONE 2014; 9: e101086
  • 78 Hummel T, Pfetzing U, Lötsch J. A short olfactory test based on the identification of three odors. J Neurol 2010; 257: 1316-1321