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Thromb Haemost 1961; 6(02): 254-260
DOI: 10.1055/s-0038-1654558
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Prephase Accelerator. Present Status

F Duckert
1   Coagulation Laboratory (Prof. F. Koller) of the Department of Medicine (Prof. P. H. Rossier) Kantonsspital, University of Zürich, Switzerland
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Publication History

Publication Date:
12 July 2018 (online)

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Summary

The properties of the prephase accelerator (PPA) are indicated as well as its differentiation from other known clotting factors. PPA is either a reaction product or a degratation product. For its normal formation genuine factor IX, PTA and ? Hageman factor are necessary.

The one-stage quantitative assay method for factor “IX” does not determine the factor lacking in haemophilia B. This method gives a measure of PPA.

Some practical observations are made concerning the value of the one-stage assay method for factor “IX” and of the thromboplastin generation test for the diagnosis of haemophilia B.

 

  • References

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