Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1961; 6(02): 254-260
DOI: 10.1055/s-0038-1654558
DOI: 10.1055/s-0038-1654558
Originalarbeiten — Original Articles — Travaux Originaux
The Prephase Accelerator. Present Status
Further Information
Publication History
Publication Date:
12 July 2018 (online)
Summary
The properties of the prephase accelerator (PPA) are indicated as well as its differentiation from other known clotting factors. PPA is either a reaction product or a degratation product. For its normal formation genuine factor IX, PTA and ? Hageman factor are necessary.
The one-stage quantitative assay method for factor “IX” does not determine the factor lacking in haemophilia B. This method gives a measure of PPA.
Some practical observations are made concerning the value of the one-stage assay method for factor “IX” and of the thromboplastin generation test for the diagnosis of haemophilia B.
-
References
- (1) Bachmann F, Duckert F, Fisch U, Streuli F, Gerber D, Koller F. Der Gerinnungsdefekt beim kongenitalen PTA-Mangel. Schweiz. med. Wschr. 88: 1037 1958;
- (2) Duckert F, Yin E. T, Straub W. Separation and Purification of the Blood Clotting Factors by means of Chromatography and Electrophoresis. Preparative Methods. Protides of the Biological Fluids. Proc. 8th Colloquium, Buges 1960. 41 Elsevier; Amsterdam: 1961
- (3) Fisch U. Über einen neuen Accelerator der Blutthrombokinasebildung. Thromb. Diath. haem. 2: 60 1958;
- (4) Fisch U, Duckert F. Some Aspects of Kinetics of the First Stages of Blood Thromboplastin Formation. Thromb. Diath. haem. 3: 98 1959;
- (5) Geiger M, Duckert F, Koller F. Quantitative Bestimmungen von Faktor VIII und F. IX bei Blutersippen. 413 Kongr. Europ. Ges. Haemat. Freiburg i. Br., 1955. Springer; Heidelberg: 1956
- (6) Straub W. Separation of Coagulation Factors by Means of Starch Gel Electrophoresis. Thromb. Diath. haem. 4: 451 1960;
- (7) Yin E. T, Duckert F. Purification of Factor IX or of its Precursor. Isolation of a Hageman-PTA Fraction. Thromb. Diath. haem. 6: 215 1961;
- (8) Yin E. T, Duckert F. The Formation of Intermediate Product I in a Purified System. The Rôle of Factor IX or of Its Precursor and of a Hageman-PTA Fraction. Thromb. Diath. haem. 6: 224 1961;
- (9) Yin E. T, Shanberge J. N, Duckert F. The Relation Between a Naturally Occuring Inhibitor and Prothrombin in Intermediate Product I Formation. Thromb. Diath. haem. 6: 248 1961;