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Thromb Haemost 1974; 32(01): 124-131
DOI: 10.1055/s-0038-1647679
Original Article
Schattauer GmbH

Electroimmunoassay of Plasma Subunits-A and -S in a Case of Congenital Fibrin Stabilizing Factor Deficiency

T Barbui
1   Division of Haematology, Regional Civil Hospital, Vicenza, Italy
,
G Cartei
1   Division of Haematology, Regional Civil Hospital, Vicenza, Italy
,
T Chisesi
1   Division of Haematology, Regional Civil Hospital, Vicenza, Italy
,
E Dini
1   Division of Haematology, Regional Civil Hospital, Vicenza, Italy
› Author Affiliations
Further Information

Publication History

Received 20 February 1974

Accepted after resubmission 18 April 1974

Publication Date:
24 July 2018 (online)

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Summary

Antigenic material related to the fibrin stabilizing factor (Factor XIII-FSF) has been found in all the examined patients with congenital deficiency, albeit in reduced amount.

Recently, Bohn et al. (1973) and Israels et al. (1973) showed that plasma Factor- XIII is composed by two subunits, A (or a) and S (or b); the former active protein, the latter probably FSF-binding protein.

Using specific anti-S and anti-A antisera the Authors found, in a case of congenital deficiency of factor XIII, absence of subunit A. Subunit S presented abnormal behaviour as demonstrated by means of quantitative immunoelectrophoresis according to Laurell.

 

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