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DOI: 10.1055/s-0038-1647679
Electroimmunoassay of Plasma Subunits-A and -S in a Case of Congenital Fibrin Stabilizing Factor Deficiency
Publication History
Received
20 February 1974
Accepted after resubmission
18 April 1974
Publication Date:
24 July 2018 (online)
Summary
Antigenic material related to the fibrin stabilizing factor (Factor XIII-FSF) has been found in all the examined patients with congenital deficiency, albeit in reduced amount.
Recently, Bohn et al. (1973) and Israels et al. (1973) showed that plasma Factor- XIII is composed by two subunits, A (or a) and S (or b); the former active protein, the latter probably FSF-binding protein.
Using specific anti-S and anti-A antisera the Authors found, in a case of congenital deficiency of factor XIII, absence of subunit A. Subunit S presented abnormal behaviour as demonstrated by means of quantitative immunoelectrophoresis according to Laurell.
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References
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