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Am J Perinatol 2015; 32(13): 1217-1224
DOI: 10.1055/s-0035-1554795
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Association of Antegrade Pulmonary Artery Diastolic Velocity with Spontaneous Closure of the Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants

Dawn M. Weiss
1   Division of Neonatology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Jeffrey R. Kaiser
2   Division of Neonatology, Departments of Pediatrics and Obstetrics and Gynecology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas
,
Christopher Swearingen
3   Division of Biostatistics, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Sadia Malik
4   Division of Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Ritu Sachdeva
5   Division of Pediatric Cardiology, Department of Pediatrics, Emory School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia
› Author Affiliations
Further Information

Publication History

11 November 2014

01 April 2015

Publication Date:
09 June 2015 (online)

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Abstract

Objective This study aims to determine echocardiographic parameters associated with spontaneous patent ductus arteriosus (PDA) closure in extremely low-birth-weight (ELBW) infants.

Study Design Retrospective demographic review and analysis of echocardiograms from 189 ELBW infants with suspected and confirmed hemodynamically significant PDA identified on an initial echocardiogram was performed. Comparison of echocardiographic parameters was made between infants with spontaneous closure versus those who received treatment.

Results The mean birth weight (787 ± 142 vs. 724 ± 141 g, p = 0.04) and gestational age (27.4 ± 2.8 vs. 26.2 ± 1.6 weeks, p = 0.03) were higher in the spontaneous closure versus the treatment group. Antegrade pulmonary artery (PA) diastolic velocity was lower in infants with spontaneous PDA closure versus those who received treatment (0.15 ± 0.06 vs. 0.22 ± 0.12 m/s, p = 0.009).

Conclusion Heavier and more mature ELBW infants with a lower antegrade PA diastolic velocity were likely to have spontaneous closure of the PDA.

Keywords

extremely low-birth-weight infant - ductus arteriosus - echocardiography
 

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