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Horm Metab Res 2012; 44(13): 975-979
DOI: 10.1055/s-0032-1316294
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Chronic Exercise Promotes Alterations in the Neuroendocrine Profile of Elderly People

E. S. Alves
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
,
H. S. Souza
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
,
J.P. P. Rosa
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
,
F. S. Lira
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
3   Laboratório de Fisiologia e Bioquímica do Exercício, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
,
G. D. Pimentel
4   Departamento de Medicina Interna, Universidade Estadual de Campinas, Brazil
,
R.V. T. Santos
5   Departamento de Biociências, Campus Baixada Santista, Universidade Federal de São Paulo, Brazil
,
L. M. Oyama
6   Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
,
A. R. Damaso
5   Departamento de Biociências, Campus Baixada Santista, Universidade Federal de São Paulo, Brazil
,
C. M. Oller do Nascimento
6   Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
,
V.A. R. Viana
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
,
R. A. Boscolo
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
,
V. Grassmann
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
,
M. G. Santana
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
7   Universidade Federal de Goiás - Campus Jataí
,
S. Tufik
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
,
M. T. de Mello
1   Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil
2   Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

received 03 March 2012

accepted 22 May 2012

Publication Date:
29 June 2012 (online)

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Abstract

Aging and physical inactivity are 2 factors that favour the development of cardiovascular disease, metabolic syndrome, obesity, and diabetes. In contrast, adopting a habitual moderate exercise routine may be a nonpharmacological treatment alternative for neuroendocrine aging disorders. We aimed to assess the effects of moderate exercise training on the metabolic profiles of elderly people with sedentary lifestyles. Fourteen sedentary, healthy, elderly male volunteers participated in a moderate training regimen for 60 min/day, 3 days/week for 24 weeks at a work rate equivalent to their ventilatory aerobic threshold. The environment was maintained at a temperature of 23±2°C, with a humidity of 60±5%. Blood samples for analysis were collected at 3 intervals: at baseline (1 week before training began), and 3 and 6 months after training. The training promoted increased aerobic capacity (relative VO2, and time and velocity to VO2max; (p<0.05)) and reduced serum α-MSH (p<0.05) after 3 months of training when compared with the baseline data. In addition, serum thyroid hormone (T3 and T4) was reduced after 6 months of training compared with baseline levels. Our results demonstrate that a moderate exercise training protocol improves the metabolic profile of older people, and metabolic adaptation is dependent on time.

Key words

aerobic capacity - neuropeptides - aging - moderate training
 

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