Chronic Exercise Promotes Alterations in the Neuroendocrine Profile of Elderly People

E. S. Alves; H. S. Souza; J.P. P. Rosa; F. S. Lira; G. D. Pimentel; R.V. T. Santos; L. M. Oyama; A. R. Damaso; C. M. Oller do Nascimento; V.A. R. Viana; R. A. Boscolo; V. Grassmann; M. G. Santana; S. Tufik; M. T. de Mello

doi:10.1055/s-0032-1316294

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2012; 44(13): 975-979
DOI: 10.1055/s-0032-1316294

Humans, Clinical

Chronic Exercise Promotes Alterations in the Neuroendocrine Profile of Elderly People

E. S. Alves

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

,

H. S. Souza

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

,

J.P. P. Rosa

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

,

F. S. Lira

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

³Laboratório de Fisiologia e Bioquímica do Exercício, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

,

G. D. Pimentel

⁴Departamento de Medicina Interna, Universidade Estadual de Campinas, Brazil

,

R.V. T. Santos

⁵Departamento de Biociências, Campus Baixada Santista, Universidade Federal de São Paulo, Brazil

,

L. M. Oyama

⁶Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil

,

A. R. Damaso

⁵Departamento de Biociências, Campus Baixada Santista, Universidade Federal de São Paulo, Brazil

,

C. M. Oller do Nascimento

⁶Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil

,

V.A. R. Viana

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

,

R. A. Boscolo

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

,

V. Grassmann

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

,

M. G. Santana

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

⁷Universidade Federal de Goiás - Campus Jataí

,

S. Tufik

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

,

M. T. de Mello

¹Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil

²Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil

› Institutsangaben

Abstract

Aging and physical inactivity are 2 factors that favour the development of cardiovascular disease, metabolic syndrome, obesity, and diabetes. In contrast, adopting a habitual moderate exercise routine may be a nonpharmacological treatment alternative for neuroendocrine aging disorders. We aimed to assess the effects of moderate exercise training on the metabolic profiles of elderly people with sedentary lifestyles. Fourteen sedentary, healthy, elderly male volunteers participated in a moderate training regimen for 60 min/day, 3 days/week for 24 weeks at a work rate equivalent to their ventilatory aerobic threshold. The environment was maintained at a temperature of 23±2°C, with a humidity of 60±5%. Blood samples for analysis were collected at 3 intervals: at baseline (1 week before training began), and 3 and 6 months after training. The training promoted increased aerobic capacity (relative VO₂, and time and velocity to VO₂max; (p<0.05)) and reduced serum α-MSH (p<0.05) after 3 months of training when compared with the baseline data. In addition, serum thyroid hormone (T3 and T4) was reduced after 6 months of training compared with baseline levels. Our results demonstrate that a moderate exercise training protocol improves the metabolic profile of older people, and metabolic adaptation is dependent on time.

Key words

aerobic capacity - neuropeptides - aging - moderate training

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Referenzen

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