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Synfacts 2011(7): 0775-0775
DOI: 10.1055/s-0030-1260503
DOI: 10.1055/s-0030-1260503
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd-Catalyzed Carboamination Reactions to Yield Saturated 1,4-Benzodiazepines
J. D. Neukom, A. S. Aquino, J. P. Wolfe*
University of Michigan, Ann Arbor, USA
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
In this work, a new synthetic access to saturated 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones via palladium-catalyzed alkene carboaminations is described. Substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with a diastereomeric ratio larger than 20:1.