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Synfacts 2011(7): 0768-0768  
DOI: 10.1055/s-0030-1260495
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Coupling of Phenylboronic Acids with Phosphonate Diesters

Contributor(s): Paul Knochel, Thomas Kunz
R. Zhuang, J. Xu, Z. Cai, G. Tang, M. Fang*, Y. Zhao*
Xiamen University, Fujian and Tsinghua University, Beijing, P. R. of China
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

The authors disclose a mild and efficient procedure for a C-P bond formation. This robust copper-catalyzed reaction proceeds by a direct coupling of phenylboronic acids and phosphonate diesters. The source of metal is the convenient and relatively inexpensive copper(I) oxide. Various functional groups and electron-donating or -withdrawing substituents are tolerated on the boronic acid moiety.