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Synfacts 2011(6): 0678-0678
DOI: 10.1055/s-0030-1260424
DOI: 10.1055/s-0030-1260424
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Activation of C(sp³)-H Bond via 1,5-Hydride Transfer-Cyclization
K. Mori, K. Ehara, K. Kurihara, T. Akiyama*
Gakushuin University, Tokyo, Japan
Further Information
Publication History
Publication Date:
19 May 2011 (online)
Significance
The authors report an asymmetric sp³ C-H functionalization reaction via an intramolecular 1,5-hydride transfer-ring-closure sequence, using chiral phosphoric acids as catalyst. N,N-Dibenzyl substrates 1 underwent a smooth internal redox process, affording various tetrahydroquinoline derivatives 2 in high yields and good to excellent enantioselectivities.