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Synfacts 2011(1): 0097-0097
DOI: 10.1055/s-0030-1259191
DOI: 10.1055/s-0030-1259191
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Dihydroquinolones Using a Bifunctional Thiourea Catalyst
X. Liu, Y. Lu*
National University of Singapore, Singapore
Further Information
Publication History
Publication Date:
21 December 2010 (online)
Significance
Lu and co-worker reported an intramolecular cyclization of activated anilines onto ester-substituted unsaturated ketones using bifunctional thiourea catalyst 1, leading to bioactive quinolone derivatives. The products were obtained in generally good yields and high enantioselectivities. The target quinolones were obtained without loss of enantiopurity after removing the N-sulfonyl group.