Download PDF
Synfacts 2010(3): 0373-0373  
DOI: 10.1055/s-0029-1219279
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki-Miyaura Coupling of Aryl Chlorides with Supported Palladium Catalyst

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
S. Schweizer, J.-M. Becht*, C. Le Drian
Institut de Science des Matériaux de Mulhouse, France
Further Information

Publication History

Publication Date:
18 February 2010 (online)

    Permissions and Reprints

Significance

Polymer-supported palladium ­catalyst 1 was prepared by the reaction of Merrifield resin with lithium tert-butylphenylphosphide, followed by treatment with tetrakis(triphenylphosphine)palladium (eq. 1). The catalyst 1 promoted the Suzuki-Miyaura cross-coupling reactions of aryl chlorides 2 with arylboronic acids 3 to give the corresponding biaryls 4 in up to 98% yield (17 examples, eq. 2).