Total Synthesis of (-)Clavirolide C

Significance

The first enantioselective total synthesis of (-)-clavirolide C is noteworthy for the use of different types of copper-catalyzed asymmetric conjugate additions to make both the fragments E and F as well as the final molecule. Also the phosphine-free ruthenium-based ring-closing metathesis to form the 11-membered ring is a rare example of its kind.