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Int J Sports Med 2022; 43(04): 336-343
DOI: 10.1055/a-1548-6985
Physiology & Biochemistry

Endurance Exercise Training reduces Blood Pressure according to the Wilder’s Principle

Ricardo Mora-Rodriguez 
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
,
Juan Fernando Ortega
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
,
Felix Morales-Palomo
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
,
Miguel Ramirez-Jimenez
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
,
Alfonso Moreno-Cabañas
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
,
Laura Alvarez-Jimenez
1   Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain
› Author Affiliations Funding This study was partially funded by a grant from the Spanish Ministry of Economy, Industry and Competivity (DEP-2017-83244-R).

Clinical Trials Registration: ClinicalTrials.gov NCT03019796
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Correction: Endurance Exercise Training reduces Blood Pressure according to the Wilder’s PrincipleInt J Sports Med 2022; 43(04): e1-e1
DOI: 10.1055/a-1676-9516

Abstract

The effect of antihypertensive medicine (AHM) is larger the higher the pre-treatment blood pressure level. It is unknown whether this Wilder’s principle, also applies for the exercise-training blood pressure (BP) lowering effect. One hundred seventy-eight (n=178) middle-aged individuals (55±8 y) with metabolic syndrome (MetS), underwent high intensity interval training (3 days·week–1) for 16 weeks. Participants were divided into medicated (Med; n=103) or not medicated (No Med; n=75) with AHM. Office BP was evaluated before and after the exercise-training. Correlations and stepwise regression analysis were used to determine which variable better predicted the reductions in systolic BP (SBP) with training. After training, participants with hypertension lowered SBP by a similar magnitude regardless of if they were in the Med (–15 mmHg, 95% CI–12,–19; P<0.001) or No Med group (–13 mmHg, 95% CI–9,–16; P<0.001). However, SBP did not decrease among normotensive groups (P=0.847 for Med and P=0.937 for No Med). Pre-treatment SBP levels was the best predictor of exercise-training lowering effect (r=–0.650; β=–0.642; P<0.001). For each 10 mmHg higher pre-training SBP there were a 5 mmHg deeper SBP reduction (Wilder principle). Furthermore, AHM does not interfere with exercise-training BP-lowering effect.

Key words

aerobic interval training - cardiovascular diseases - hypertension - metabolic syndrome - office blood pressure - Wilder’s principle


Publication History

Received: 02 January 2021

Accepted: 30 June 2021

Article published online:
24 September 2021

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