DOI:
10.1055/s-00000083
Synlett
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Eto M. Naruse N. Morimoto K. Yamaoka K. Sato K. Tsuji K. Inokuma T. Shigenaga A. Otaka A.
Org. Lett. 2016;
18: 4416 General Procedure
Under Ar atmosphere, Fmoc-Xaa-OH (Xaa = Leu or Ser(t-Bu), 0.50 mmol) was coupled on an H-Dbz(NO2)-rink amide resin (45 mg, 0.025 mmol) using POCl3 (78 μL, 0.50 mmol) and 2,4,6-trimethylpyridine (66 μL, 0.50 mmol) in THF (4.0 mL) at 40 °C for 16 h. In case of Gly, Fmoc-Gly-OH (0.25 mmol) was coupled on an H-Dbz(NO2)-rink amide resin (45 mg, 0.025 mmol) using POCl3 (39 μL, 0.25 mmol) and 2,4,6-trimethylpyridine (33 μL, 0.25 mmol) in THF (4.0 mL) at 40 °C for 16 h under Ar atmosphere.
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