Synfacts

Issue 12 · December 2025

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Synthesis of Natural Products
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1175
Total Synthesis of (+)-Elisapterosin F
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1176
Total Synthesis of (–)-Novofumigatonin

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1177
Total Synthesis of (±)-Calyciphylline F

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1178
Total Synthesis of (–)-Psychotriadine

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1179
Total Synthesis of (±)-Crokonoid A

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1180
Total Synthesis of (–)-Thaigranatin P

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1181
Total Synthesis of (–)-Vindoline
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Synthesis of Heterocycles
z1183
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1183
Modular Access to Azabicyclo[2.2.2]octanes and Related Azabicycles
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1184
A Vilsmeier–Haack Reaction to Selectively Access Nicotinaldehyde Derivatives

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1185
A Mild and Irreversible Conversion of Indazoles into Benzimidazoles

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1186
Efficient Access to Chiral N-Substituted Pyrrolidines

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1187
Cascade Ring Expansion to Access Functionalized Lactones

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1188
Robust C2-Selective Deprotonation of Pyridines

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1189
Ring Structure Diversification from Quinoline N-Oxides

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1190
Synthesis of Fluorinated Isoxazolines Using a New gem-Difluoroalkane Precursor

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1191
Synthesis of Benzothiadiazine 1,1-Dioxides through Iodine-Mediated Oxidative Cyclization

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1192
One-Pot Access to N–H β-Amino γ-Lactones via Rhodium-Catalyzed Alkene Oxyamination

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1193
Pd-Catalyzed Reaction of Arylsilanes and gem-Difluorocyclopropanes with a Fluoride Source

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1194
[2+2]-Cycloaddition for the Synthesis of Azetidines

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Synthesis of Materials and Unnatural Products
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1195
A Catenane-Stabilized Cyclo[48]carbon
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1196
Laterally π-Extended Helical Nanographenes

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1197
Narrow Deep-Blue Emitting BN/BO-Embedded Polycycles from Lithium-Free Borylation

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1198
Conjugated Polymers with Planarized B=P Connectivity

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1199
Triquino[3]radialene Re-visited

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1200
Benzophosphole Oxides via Phosphinyl-Zincation

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1201
3D-Printable Thermosets with N,O-Acetal-Enabled Degradability and Recyclability

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1202
Solvent-Tuned Upcycling of Polyethylene Terephthalate to Biodegradable Polymer Monomers

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1203
Preparation and Graft-Polymerization of On-Chain Polyhydroperoxides

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1204
Living Cationic Polymerization of Oxiranes

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Metals in Synthesis
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1205
Regio- and Stereoselective trans-Hydrostannation of Terminal Alkynes Enabled by an Iron Catalyst
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1206
Asymmetric Reductive Vinylation of Imines under Dinickel Catalysis
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1207
Synthesis of Tetrahydropyridines via a Cu-Catalyzed Formal [5+1]-Cycloaddition of Vinylcyclopropanes

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1208
Isonitriles as Alkyl Radical Precursors in Photoinduced Palladium-Catalyzed Mizoroki–Heck Cross-Coupling

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1209
Ligand-Enabled Non-Directed C–H Alkenylation of Arenes with α-Trifluoromethyl Olefins

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1210
Palladium-Catalyzed 1,4-syn-Chloroalkylamination of 1,3-Dienes to Access Isoquinuclidines

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1211
Ruthenium-Catalyzed Regioselective [2+2] Cycloaddition of Allenes and Alkynes

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1212
A Reductive Alkylation/Aldol Strategy to Access β-Hydroxy Carboxyl Compounds via Dual Catalysis

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1213
Photoredox Cyclopropanation via Boryl Radical-Mediated Carbene Formation

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1214
Nickel-Catalyzed Asymmetric Hydroalkylation of Unsaturated Cyclic Phosphinates

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1215
Copper-Catalyzed Construction of Six-Membered Phosphorus(V) Heterocycles

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1216
Samarium Diiodide Induced Radical Deuteration of Thioacids in D₂O

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1217
Copper-Catalyzed Radical Deoxyalkynylation of Unactivated Aliphatic Alcohols

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1218
Copper-Catalyzed Hydroamination of Alkynes Leads to the Selective Synthesis of Axially Chiral Enamines

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1219
A Monodentate Benzofuran Phosphine Ligand Enables Isomerization of Allylamines under Cobalt Catalysis

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1220
Divergent Synthesis of Hexacyclic Heterocycles Using Gold or Silver Catalysis

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1221
Diastereoselective Cyclopropanation with Catalytically Generated Alkyl−Iodine(III)-Rhodium(II) Carbynoids

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1222
Iridium-Catalyzed Dynamic Kinetic Resolution/Asymmetric Hydrogenation of α-Substituted Ketones

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1223
Enantioconvergent Synthesis of Alkyl Azides from α-Haloamides by Photoinduced Copper Catalysis

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1224
Hydroarylation of Strained Heterobicycles via a Rhodium-Catalyzed Directed C–H Activation

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1225
Synthesis of Skipped Enones by Nickel-Catalyzed Dehydrogenative Coupling of Aldehydes and Alkenes

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1226
Copper-Catalyzed Regiodivergent Hydrosilylation of α, β-Unsaturated Esters

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1227
Regioselective Hydro- and Haloazidation of Alkenes under Iron Photocatalysis

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1228
Stereo- and Regiodivergent Hydrogenation of Allenes under Cobalt Catalysis

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1229
Iridium-Catalyzed Asymmetric 1,3-Hydroalkynylation of Allylamides

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1230
Synthesis of Vinylcyclobutanecarboxamides through a Pd-Catalyzed Three-Component Aminocarbonylation

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Polymer-Supported Synthesis
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1231
C−S Coupling of Thiols and Aryl Iodides Using a Copper Single-Atom Catalyst Supported on mpgCN
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1232
Asymmetric Reactions Using Sc(OTf)₃ or Cu(OTf)₂ Supported on PyBOX-Contained COF

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1233
Selective Aerobic Dehydrogenative Aromatization Using Ceria-Supported Gold Nanoparticles

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1234
Synthesis of 1,2,3,4-Tetrahydroquinolines from 2-Nitrobenzaldehydes and Ketones Using Ni Nanoparticles

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1235
A Polymeric Pd-BINAP Catalyst for the Buchwald–Hartwig Cross-Coupling

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1236
Pd-NHC-COF Catalyzes the Suzuki–Miyaura and Mizoroki–Heck Cross-Couplings

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1237
C2-Amidation of Quinoline N-Oxides Using a Nitrogen-Doped Carbon-Supported Fe Catalyst

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1238
Photocatalytic Oxygenation of 2-Oxazolidinones Using an Anthraquinone–Resorcinol Based Polymer

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1239
Asymmetric C3-Allylation of Tryptophols and Tryptamines Using a Polymer-Supported Ir Catalyst

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1240
H⁺-Modulated Electrochemical Olefin Hydrogenation and Olefin Migration with Nickel Catalysts

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1241
Asymmetric Transfer Hydrogenation with a Mesoporous Silica-Grafted Polymeric Ru-DPEN Catalyst

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Organo- and Biocatalysis
z1243
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1243
Harnessing Radical Polarity Effects for Hydroalkylation of Unactivated Alkenes with Amides
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1244
Unlocking the (ene–endo)-Mode of Carbonyl–Ene Cyclizations

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1245
Flavin-Catalyzed Generation of p-Quinone Methides for Benzylic Functionalization of Phenols

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1246
Regio- and Stereoselective Dehydration of Tertiary Vinyl Alcohols – More than Kinetic Resolution

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1247
Chiral Disulfide Catalyst for Enantioselective Anti-Markovnikov Hydrophosphinylation

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1248
N-Heterocyclic Carbene Enabled Umpolung Strategy for Constructing Rigid Bicyclic Scaffolds

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1249
Asymmetric Synthesis of Sulfonimidoyl Derivatives via Control of Sulfur(VI) Stereogenicity

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1250
Class I Unspecific Peroxygenase Catalyzed Conversion of Furans into Pyrrolinones

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1251
Organocatalyzed Synthesis of BN-2,1-Azaboranaphthalenes via a Wolff-Type Rearrangement

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Innovative Drug Discovery and Development
z1253
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1253
Facile Nitrone Synthesis Enables Bioorthogonal Payload Delivery
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1254
Conversion of Primary Aliphatic Amines into Alkyl Halides

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1255
Cs₂CO₃-Mediated Metal-Free Nitrogen Heterocycle Synthesis

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1256
Directing-Group-on-Leaving-Group Strategy Enables General and Stereospecific Glycosylation

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1257
PULIng It Together: Self-Condensation Photoassembly of Pyronin Dyes for Super-Resolution Microscopy

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1258
Improved Synthesis of Resmetirom

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1259
Single-Component Guanidinium Transporters Enable Directed mRNA Delivery

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1260
Novel Multi-Target-Directed Derivatives as Potential Therapeutic for Alzheimer’s Disease

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1261
Design of Theranostic Prodrug for Targeted Imaging and Drug Delivery

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Peptide Chemistry
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1263
Photocatalytic Side-Chain Deprotection in SPPS via Fmoc/Pic Chemistry: A Sustainable Alternative to TFA
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1264
Tris(2,2,2-trifluoroethoxy)silane: A New Reagent for N-Terminal Free Peptide Synthesis

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1265
A Reusable Sulfonate Derivative of HOAt for Efficient Amide Bond Formation

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1266
Synthesis of Unnatural α-Amino Acid Esters Utilizing a Half-Sandwich Chiral-at-Ruthenium Aldehyde Catalyst

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1267
Synthesis of ¹³C-Labeled α-Amino Acids via Visible-Light-Driven Benzylic C(sp³)–H Carboxylation

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1268
Synthesis of α-Amino Esters by Enantioselective N–H Insertion of Sulfonamides and Carbamates

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1269
Photocatalytic Late-Stage Modification of Tryptophan-Containing Peptides

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1270
Native Chemical Ligation of Oligopeptides Using α-Ketoacids and Cyclic Hydroxylamine

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1271
Claisen Rearrangement for the Synthesis of γ,δ-Unsaturated Amino Acid Esters
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Flow Chemistry
z1273
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1273
UV-B Initiated Decarboxylative Synthesis of Trisubstituted Oxazoles in Flow

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