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Synfacts 2025; 21(12): 1206
DOI: 10.1055/a-2720-7480
DOI: 10.1055/a-2720-7480
Metals in Synthesis
Asymmetric Reductive Vinylation of Imines under Dinickel Catalysis
Authors
Zhou P,
Wang P,
Zhu H,
Zhang J,
Peng Q *,
Tao Z *.
Nankai University, Tianjin, Hunan University, Changsha, and Hunan University, Guangzhou,
P. R. China
Dinickel-Catalyzed Enantioselective Reductive Addition of Imines with Vinyl Halides.
Nat. Commun. 2025;
16: 8871
DOI: 10.1038/s41467-025-63940-y
Dinickel-Catalyzed Enantioselective Reductive Addition of Imines with Vinyl Halides.
Nat. Commun. 2025;
16: 8871
DOI: 10.1038/s41467-025-63940-y
Significance
Peng, Tao and co-workers report an elegant synthesis of enantioenriched allyl amines and allyl alcohols under dinickel catalysis. The reaction conditions exhibit broad functional group tolerance including other halides and boronic esters.
Comment
Mechanistic studies support two-electron processes throughout the reaction. Exposure of the reaction to DNPO led to comparable yields and enantioselectivities. A cyclopropyl imine substrate did not undergo ring opening.
Publication History
Article published online:
26 November 2025
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