DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 21 · March 2025 DOI: 10.1055/s-015-61120

Synthesis of Natural Products

  • z221

    All PDFs of this category

  • 221

    Total Synthesis of (–)-Scabrolide B

  • 222

    Total Synthesis of (+)-Kalmanol

  • 223

    Total Synthesis of (+)-Hyperbeanol A

  • 224

    Total Synthesis of (+)-Euphorbialoid A

  • 225

    Total Synthesis of (−)-Macrocalin B

  • 226

    Synthesis of (+)-Mannolide B

  • 227

    Synthesis of (–)-Strychnine

    • Synthesis of Heterocycles

  • z229

    All PDFs of this category

  • 229

    Manganese-Catalyzed Ring Expansion of Cycloalkenes To Access Pyridines and Isoquinolines

  • 230

    Expanding Scope of Carbonylative Alkylative Amination

  • 231

    Ligand-Controlled Synthesis of Azepine Derivatives

  • 232

    Pd-Mediated Synthesis of Fused Azetidines/Oxetanes

  • 233

    Diastereoselectivity Switch in the Synthesis of Spirocyclic Pyrrolidine Derivatives

  • 234

    Electrochemically Mediated Synthesis of Cycloalkanes

  • 235

    Orthogonal Approach to Aminated Heterocyclic Derivatives

  • 236

    Visible-Light-Induced Radical Cyclization To Access Sulfamoylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones

  • 237

    Base-Free Borylation of Aryl Bromides/Iodides Promoted by Zinc

  • 238

    Synthesis of Tetrahydroquinolines from N-Benzylhydroxylamines and Alkenes in HFIP Solvent

  • 239

    A Tandem Amination/Cyclization of Quinazolin-4(3H)-imines

    • Synthesis of Materials and Unnatural Products

  • z241

    All PDFs of this category

  • 241

    Aromatic-Ring-Opening Metathesis

  • 242

    Boron-Facilitated N/C Atom Swapping in Triple Bonds

  • 243

    Benzo-2-azaboroles

  • 244

    Poly(p-phenylene iminoborane)

  • 245

    High MW Polyesters from Tishchenko Polymerizations

  • 246

    Stable Triplet Metallocarbenes

  • 247

    Stable High-Spin Hydrocarbon-Based Diradical

  • 248

    Enantioselective Synthesis of Helical Bilayer Nanographenes

  • 249

    Diameter-Controlled Growth of Single-Walled Carbon Nanotubes from Organic Nanobelts

  • 250

    Graphene-Like Covalent Organic Frameworks

  • 251

    Double-Hoop Cycloparaphenylene (CPP)

  • 252

    Decafluoroanthracene

    • Metals in Synthesis

  • z253

    All PDFs of this category

  • 253

    Synthesis of Spirocyclic Oxaheterocycles via a Copper-Catalyzed Cyclization Alkene Transposition Sequence

  • 254

    Copper-Catalyzed Enantioselective Acyloxylation of Activated C(sp3)−H Bonds with Carboxylic Acids

  • 255

    Synthesis of Aza- and Oxoheterocycles from Alkenyl Amines and Alkenyl Alcohols under Palladium Catalysis

  • 256

    Stereodivergent Access to Glutamic Acid Derivatives under Pd/Cu Dual Catalysis

  • 257

    Rhodium-Catalyzed (Z)-Alkenyl Transfer to Aryl Ketones and Chalcones from Tertiary Allylic Alcohols

  • 258

    Accessing Asymmetric Spirooxindoles via Divergent [3+2] and [3+3] Cycloadditions on Cu-Allenylidenes

  • 259

    Remote Desaturation of Aliphatic Silyl Ethers under Dual Photoredox and Cobalt Catalysis

  • 260

    Enantioconvergent Difluoromethylation of α-Haloamides under Copper Catalysis

  • 261

    NiH-Catalyzed Polarity-Reversed Functionalization of Aliphatic Aldehydes

  • 262

    Difluoroalkylation of Alkenes via Visible-Light-Induced Palladium Catalysis

  • 263

    Switchable Site-Selective C(sp3)─H and C(sp2)─H Functionalization via Cp*CF3Ir(III) Catalysis

  • 264

    Copper-Catalyzed Synthesis of Naphthols from Enaminones and 1,3-Dicarbonyl Compounds

  • 265

    Synthesis of Fluorinated Bicyclo[4.1.1]octenes via (4+3) Annulation of BCBs and gem-Difluoroalkenes

  • 266

    Synthesis of Cyclopentanones with Contiguous All-Carbon Quaternary Stereocenters under Nickel Catalysis

  • 267

    Selective Alkylations and Alkenylations of Quaternary Ammonium Salts Using Photocatalysis

  • 268

    Asymmetric α-Alkylation of 2-Acylimidazoles by Copper(I) Catalysis

  • 269

    Use of Strained Vinyl BCBs in a [2σ+2π] Cycloaddition Catalyzed by Palladium

  • 270

    Site-Selective Hydrogenation of Amides Enabled by a Bifunctional Copper(I)/NHC–Guanidine Catalyst

  • 271

    [2+1] Enabled Skeletal Editing of N-Heterocycles

  • 272

    Making Dinitriles from Cyclic Ketones by a Copper-Catalyzed Aerobic Ammoxidation Reaction

  • 273

    Functionalization of Sulfonamides via a Multicomponent Cobalt-Catalyzed C–H Activation

  • 274

    Nickel-Catalyzed Asymmetric Intramolecular Hydroamidation of N-Alkenyl Formamides to γ-Lactams

  • 275

    Copper-Catalyzed Multicomponent Synthesis of Anilines

  • 276

    Photonitration of Arenes Using Iron(III) Nitrate as Nitrogen Dioxide Source

  • 277

    Double Nickel Migration Leads to the Synthesis of Silaindanes

  • 278

    Enantio- and Stereospecific Synthesis of β-Lactams via Ring Expansion of Aziridines under Rhodium Catalysis

    • Polymer-Supported Synthesis

  • z279

    All PDFs of this category

  • 279

    Oxidative Cleavage of Alkenes Promoted by a COF-Supported Fe Complex under Photoirradiation

  • 280

    Synthesis of 4-Aryl-3-sulfonylquinolines through Radical Cascade Annulation Using a W2C Photocatalyst

  • 281

    Photocatalytic Coupling of N-Heteroarenes and Alkanes/Ethers with Ce-Doped g-C3N4 and Bu4NCl

  • 282

    Deoxygenative C2 Arylation of Quinoline N-Oxides with Phenylhydrazines Using Porous Tubular Graphitic C3N4

  • 283

    Cyclization of Homopropargylic Amines and CO2 Promoted by Cu Nanoparticles Supported on MOFs

  • 284

    Photo-Induced Oxidative Hydroxylation of Aryl Boronic Acids Using COF

  • 285

    Visible-Light-Switchable Oxidation of Benzyl Alcohols Using NiOOH Electrocatalyst

  • 286

    Synthesis of Isoindolones through C–H Activation and Annulation Using Pd/Cu Nanoparticles

  • 287

    Automated On-Resin Synthesis of Oligosaccharides Bearing a Phosphoethnolamine Unit

  • 288

    On-Resin Mukaiyama Oxidation–Reduction Thioesterification for Peptide Synthesis

  • 289

    α-Alkylation of Nitriles with a Nano Cobalt Catalyst Supported on a Porous N-Doped Carbon

    • Organo- and Biocatalysis

  • z291

    All PDFs of this category

  • 291

    Unveiling and Engineering the Reverse Catalytic Potential of ‘Ene’-Reductases

  • 292

    A Benzo[ghi]perylene Monoimide Photocatalyst Defluorinates ‘Forever Chemicals’ under Visible Light

  • 293

    Intermolecular Electrocatalytic Cyclopropanation of Alkenyl Trifluoroborates with Methylene Compounds

  • 294

    Photocatalytic Reduction of Benzenes to Cyclohexenes

  • 295

    Oxidative Desymmetrization of meso-Diols via Photo and Base Catalysis

  • 296

    Asymmetric SET–NHC Catalysis in Three-Component Dicarbofunctionalizations

  • 297

    Enzymatic Enantioselective Radical Trifluoromethyl Azidation of Styrenes

  • 298

    Chiral-Isothiourea-Catalyzed [1,2]-Rearrangement of Ammonium Ylides

  • 299

    Catalytic Enantioselective Synthesis of 1,4-(Hetero) Dicarbonyl Compounds through α-Carbonyl Umpolung

    • Innovative Drug Discovery and Development

  • z301

    All PDFs of this category

  • 301

    A Radical Approach to Secondary and Tertiary Amines

  • 302

    Metal-Free Amination of (Hetero)aryl Boronic Acids

  • 303

    Potassium Pivalate and Alcohol Cosolvents Enhance the Efficiency and Scalability of Miyaura Borylations

  • 304

    1,4-Metallate Migration Enables the Direct Synthesis of Organosulfates from Organoboron Compounds

  • 305

    Late-Stage E-to-Z Photoisomerization of Pharmaceuticals and Oligopeptides

  • 306

    Highly Efficient Conversion of Nitriles into Alcohols

  • 307

    Fluorine at the Forefront: Transforming Opioid Antagonism with C(20)-Modified Orvinols

  • 308

    Photochemical [4+2] Annulation of Silylimines to Access 1-Aminotetralins

  • 309

    Ruthenium-Catalyzed Carbocycle-Selective Asymmetric Hydrogenation of Fused N-Heteroarenes

  • 310

    (1R,3aS,4S)-Octahydro-1,4-methanopyrrolo[3,4-c]pyrrole, a Potential Piperazine or 4-Aminopiperidine Mimetic

  • 311

    Targeted Degradation of an ‘Undruggable’ Protein Scaffold to Treat Neuroblastoma

  • 312

    An Artificial Photoenzyme with a Thioxanthone Amino Acid Forms a Highly Strained Azetidine–Indole Scaffold

  • 313

    Synthesis of Eglumegad

    • Peptide Chemistry

  • z315

    All PDFs of this category

  • 315

    Synthesis of β-Amino Acids from α-Amino Acids Using Visible-Light Photoredox Catalysis

  • 316

    Copper-Photoredox-Catalyzed Site-Selective Arylation and Alkylation of Glycine-Containing Peptides

  • 317

    TfOH-Mediated Late-Stage Functionalization of Tryptophan Peptide Residues

  • 318

    NHC-Catalyzed β-Keto Amino Acid Synthesis from Aldehydes and Imines

  • 319

    Copper-Catalyzed C(sp3)–H Benzylation at the α-Position of Glycine Derivatives

  • 320

    A New Coupling Reagent with No Heteroatomic Bonds for Amidation

  • 321

    Mn(OAc)3·2H2O-Mediated Phosphorylation of Dehydroamino Acids

  • 322

    A Liquid-Phase Peptide Synthesis (LPPS) Support for the Synthesis of Octreotide

  • 323

    Racemization-Free Visible-Light-Mediated Synthesis of Peptides

  • 324

    Synthesis of Unnatural Cyclic Peptides via Cu-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides

  • 325

    Synthesis of Peptoids by a Flow Reaction Avoiding Undesired Diketopiperazine Formation

  • 326

    Accessing Photoswitchable Peptides by Embedding Spiropyrans in the Backbone of Peptides

  • 327

    A Facile Route to Accessing an Unusual Bicyclic Melanocortin-3 Receptor Antagonist: Compound 11

  • 328

    PTC-Catalyzed Asymmetric Alkylation of Glycine Imines for the Synthesis of Unnatural Amino Acid Esters

    • Flow Chemistry

  • z329

    All PDFs of this category

  • 329

    Electrochemical C–O and C–N Arylation Using Alternating Polarity in Flow