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Synfacts 2025; 21(03): 328
DOI: 10.1055/a-2518-2534
DOI: 10.1055/a-2518-2534
Peptide Chemistry
PTC-Catalyzed Asymmetric Alkylation of Glycine Imines for the Synthesis of Unnatural Amino Acid Esters
Lygo B,
Allbutt B *.
University of Nottingham, UK
Asymmetric PTC Alkylation of Glycine Imines: Variation of the Imine Ester Moiety.
Synlett 2004; 326-328
DOI: 10.1055/s-2003-43368
Asymmetric PTC Alkylation of Glycine Imines: Variation of the Imine Ester Moiety.
Synlett 2004; 326-328
DOI: 10.1055/s-2003-43368

Significance
Asymmetric alkylation is a powerful tool in organic synthesis to synthesize optically active molecules. In 2004, Lygo et.al developed a quaternary-ammonium-derived phase-transfer-catalyst-catalyzed asymmetric alkylation of glycine imines for the synthesis of unnatural amino acid esters.
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Comment
A series of unnatural amino acid esters were synthesized by asymmetric phase-transfer alkylation of various glycine imine esters. This reaction proceeded smoothly to deliver the desired products in good yields and with excellent optical purities.
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Publication History
Article published online:
25 February 2025
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