DOI: 10.1055/s-00000131

Synfacts

Issue 02 · Volume 20 · February 2024 DOI: 10.1055/s-014-58906

Synform

A022
Zanda, Matteo: SYNFORM ISSUE 2024/02

Synthesis of Natural Products

z0111
All PDFs of this category
0111
Synthesis of (±)-Aleutianamine
0112
Total Synthesis of (–)-Taxol
0113
Total Synthesis of (+)-Discorhabdin V
0114
Total Synthesis of (–)-Cyclopamine
0115
Total Synthesis of (+)-Acremolactone B
0116
Isolation and Bioinspired Synthesis of (+)-Orientanoid A
0117
Synthesis of the Rubrolone Aglycon

Synthesis of Heterocycles

z0119
All PDFs of this category
0119
Heteroarene Functionalization Using Solid Gas-MOF Reagents
0120
Ring-Opening the Door to Amination: Nitrobenzene-Derived Azepines as Key Intermediates for N-Arylation
0121
Skeletal Editing of Indoles and Pyrroles by LiHMDS Nitrogen Insertion Reaction
0122
Efficient Access to Novel Vinyl Indomorphan Scaffolds
0123
One-Pot Synthesis of Disubstituted Nicotinonitriles
0124
Copper-Catalyzed Synthesis of Pyrozles from Sydnones and Sydnomines
0125
Photoredox/Cobalt-Catalyzed Cascade Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles
0126
Radical-Mediated Synthesis of Isoquinolines
0127
Bi-Catalyzed Trifluoromethylation Using CF3SO2Cl
0128
Intramolecular Diels–Alder Cascade to Access 6- or 7-Aza-Indazoles
0129
Metal-Controlled Regioselective Synthesis of Imidazoles and Pyrroles from 2H-Azirines
0130
Palladium-Catalyzed Asymmetric C–H Functionalization Reactions
0131
sp2–sp3 Coupling of Unprotected Halogenated Anilines with Grignard Reagents

Synthesis of Materials and Unnatural Products

z0133
All PDFs of this category
0133
Conjugated [5]Cumulene Polymers from Propargylic Monomers
0134
Tetrafluorenofulvalene: To Be Single or Double?
0135
1,2-Azaborines via Ring-Opening Benzannulation
0136
Ring Expansion Polymerization via Alkyne Metathesis
0137
B2,N4-Doped Heptacene
0138
Mild Aryne Generation from Triaryloxonium
0139
Chiral Emissive Corral-Like Macrocycles
0140
Facile Ipso-Nitration of Organosilanes
0141
Tetrahedral Nanographene
0142
Ring-Size Controlled Racemization
0143
Phthalimides from Maleimides and Triethylamine
0144
Anthracene with Continuous B–N Bonds

Metals in Synthesis

z0145
All PDFs of this category
0145
Nickel-Catalyzed Hydrocyanation of Alkynes Using a Malononitrile as Transnitrilation Reagent
0146
Asymmetric Intramolecular Oxyamination of Alkenes Enabled by a Chiral-at-Ruthenium Catalyst
0147
Photoelectrocatalyzed Synthesis of Chiral Cyclobutanes
0148
Synthesis of Atropoisomeric Dienes via Enantioselective Rhodium-Catalyzed Hydroarylative Cyclization
0149
Synthesis of Functionalized Alkynes via Regioselective Ni-Catalyzed Hydroalkynylation
0150
Photochemical Amination of Aryl Chlorides Using Werner Salt
0151
Fe/Blue Light Catalyzed Electrophilic Aromatic Substitution of Acyl Nitrene Precursors
0152
Rhodium/CPA Co-Catalyzed Multicomponent Synthesis of Chiral β-Amino Esters
0153
A General Photochemical Protocol for Alkene Hydrofluoroalkylation under Iron and Thiol Catalysis
0154
Stereoconvergent Synthesis of Z-Allylsilanes by Iron-Catalyzed 1,4-Hydrosilylation of Conjugated Dienes
0155
Synthesis of Allylated Arenes via Ruthenium-Catalyzed Aromatic C–H Allylation
0156
Synthesis of Chiral Alkynes via Ni-Catalyzed Cross-Electrophile Coupling
0157
Hydroxylation of Free Amines Using a Palladium(CarboxPyridone) Catalytic System
0158
Synthesis of δ-Lactams via Biomimetic Polycyclization Initiated by an Iridium Acylnitrenoid Transfer
0159
Iridium-Catalyzed Terminal C(sp3)–H Amidation of Internal Alkenes via Olefin Chain Walking
0160
Enantioconvergent Reductive Nickel Catalysis Enables Access to Chiral 2-Alkyl-Pyridines
0161
Rhodium-Catalyzed Dynamic Kinetic Asymmetric Fluorination of Racemic Trichloroacetimidates
0162
Enantioconvergent C(sp3)–C(sp2) Stille Cross-Coupling under Photoredox/Nickel Catalysis
0163
Fluorolocatonization of Ene-Carboxylic Acid via Pd-Catalyzed Dyotropic Rearrangement
0164
Hiyama Cross-Coupling of Aryl Chlorides with Aryl Trimethoxysilanes using Pd(NHC) Precatalysts
0165
Mild Access to Aryl–Alkyl Ketones Enabled by Photoinduced Nickel Catalysis
0166
An Electrochemical Approach to the Copper-Catalyzed Azidocyanation of Alkyl and Aryl Alkenes
0167
Ruthenium-Catalyzed Intermediate Kinetic Resolution to Access Two Chiral Products
0168
Photocatalyzed Synthesis of Tricyclic Aza-Arenes by Pyridyl Radical Trapping with Diynes and Dienes
0169
Decarboxylative Difunctionalization of Alkenes Enabled by Nickel/Photoredox Catalysis
0170
The Murahashi Reaction: Palladium-Catalyzed Cross-Coupling of Vinyl Halides with Organolithium Reagents

Polymer-Supported Synthesis

z0171
All PDFs of this category
0171
Cross-Coupling Reactions Catalyzed by Regularly Spaced Copper Atom Pairs on Polymeric Carbon Nitride
0172
C(sp3)–H Amination of Alkanes by Pd Nanoparticles on Gallium Nitrides
0173
Cyclization of Propargylamines with CO2 Catalyzed by a Ag4 Nanocluster
0174
A3 Coupling Catalyzed by a Tridentate Cu–NHC Nanocluster
0175
N-Alkylation of Anilines with Primary Alcohols by MOF-Derived CoNx Nanoparticles on N-Doped Carbon
0176
Hydrodeoxygenation of Aromatic Ketones and Aldehydes, and Benzylic Alcohols Using Co/CoOx
0177
An Imidazolium-Functionalized Cage Catalyst for Site-Selective C(sp3)–H Chlorination of Amides
0178
Borylation with an N-Heterocyclic Carbene-Borane and a CdS Photocatalyst
0179
The Suzuki–Miyaura Coupling by a Reduced Polynuclear Palladium Complex Supported on Alumina
0180
Transfer Hydrogenation of Azo Compounds with MeOH or EtOH by a Cobalt Single Atomic Catalyst
0181
N-Arylation of Amides with Aryl Halides Catalyzed by a CuO Nanoplate

Organo- and Biocatalysis

z0183
All PDFs of this category
0183
Enzymatic Hydrogen Atom Transfer Allows for Remote Stereocontrol Using Aza-arenes
0184
Tuning Electron Donation Capacity Enables Regio-divergent NHC/Base-Catalyzed Aminolactone Synthesis
0185
Enantioselective Construction of Bicyclo[2.1.1]hexane Bioisosteres
0186
Enantioselective α-Arylation of β-Keto Amides with Arynes Enabled by Phase-Transfer Organocatalysis
0187
Organocatalytic Highly Selective Nitroso-Diels–Alder Reaction of Conjugated Trienes
0188
One-Pot Trifluorination/Cyclization Cascade Enabled by I(I)/I(III) Catalysis
0189
Photocatalysis-Enabled Alkylation of C(sp3)–H Bonds with Sulfonylhydrazones
0190
Organocatalytic Asymmetric Decarboxylative Protonation of Aminomalonic Acids
0191
Stereoconvergent Biocatalysis – The Conversion of E/Z-Silyl Enol Ethers into Enantiopure α-Branched Ketones
0192
Acid-Catalyzed Ring-Opening Olefination of Carbonyl Compounds Using Cyclic Ketals

Innovative Drug Discovery and Development

z0193
All PDFs of this category
0193
Enantioselective Indole C3 Oxidation
0194
Predicting Late-Stage C–H Borylations of Drug Molecules
0195
Chiral Lithium Amide Improves Stereoselectivity and Yield of Tuberculosis Drug Bedaquiline
0196
A Rh(III)-Catalyzed C–H Activation/[5+2] Annulation Sequence Allows Access to 1,2-Diazepinones
0197
Cyclopropanation: Vitamin B12 as Photoredox Catalyst
0198
Discovery of [11C]MK-8056: A Selective mGluR2 Negative Allosteric Modulator PET Tracer
0199
Introducing Boronaphthoids as the New Boron-Containing Drug Chemotypes
0200
One-Pot Hydrogenation Allows for Quick Accesses to Pharmaceuticals
0201
Photochemical Synthesis of a Cubyl Derivative of Dapsone
0202
Phosphine Catalysis of the Fluorination of Unactivated Tertiary Alkyl Chlorides under Mild Conditions
0203
Regiodivergent Access to ortho-Functionalized Anilines via Photoexcitation of Aryl Azides
0204
Radical Bicyclopentylation of Alcohols
0205
Total Synthesis of Opioid Precursor (−)-Thebaine
0206
Total Synthesis of Nimbolide and its Analogues
0207
Photocatalyzed [2+2] Cycloadditions of 1,3,2-Dioxaboroles to Alkenes to Afford Cyclobutanes and 1,4-Dicarbonyls
0208
Radical [4+1] Annulation Allows for Late-Stage Indole Synthesis
0209
Stereodivergent Synthesis of 3,3′-Disubstituted Oxindoles by N-Heterocyclic Carbene/Nickel Catalysis

Peptide Chemistry

z0211
All PDFs of this category
0211
Atom-Economical N-to-C Peptide Elongation
0212
Three-Component Reaction of Diazoacetates, Sulfonamides, Imines to Form Unnatural Amino Acids
0213
Regio-Selective Arylation Reaction for the Trp-Unit of Oligopeptides
0214
Copper-Catalyzed Asymmetric Arylation to Synthesize β-Amino Ester Precursor
0215
Electrochemical Arylation of Cysteine-Containing Peptides
0216
Microwave-Assisted Transamidation of Boc-Activated Secondary Amides
0217
Late-Stage C3Ar Functionalization of Tyrosine and Tyrosine-Containing Peptides with Maleimides
0218
Nucleophilic Hydrazide-Catalyzed Chlorination of Tyrosine-Containing Peptides
0219
Synthesis of α-Quaternary Amino Esters via Intramolecular Rearrangement
0220
Synthesis of N-Aryl Amino Acid Esters

Flow Chemistry

z0221
All PDFs of this category
0221
Simmons–Smith Cyclopropanation in Flow
0222
Continuous-Flow Chemoenzymatic Enantioselective Synthesis of Chiral α-Fluoromethyl Amines