DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 15 · November 2019 DOI: 10.1055/s-009-44705

Synform

A162
Zanda, Matteo: SYNFORM ISSUE 2019/11

Synthesis of Natural Products and Potential Drugs

z1215
All PDFs of this category
1215
Nanomolar Inhibitor of Trypanosoma brucei Trypanothione Reductase
1216
Total Synthesis of (±)-Atlanticone C
1217
Total Synthesis of Illisimonin A
1218
Artificial Intelligence Guides the Synthesis of SCH 47949
1219
Synthesis of the Immunosuppressant FR252921
1220
Synthesis of GSK2798745
1221
Synthesis of (±)-Rhabdastrellic Acid A
1222
Total Synthesis of (–)-Himeradine A
1223
Synthesis of (+)-Jungermatrobrunin A
1224
Synthesis of Antibacterial LpxC Inhibitors
1225
Synthesis of Esketamine
1226
Synthesis of (±)-Isocomene
1227
Synthesis of Omecamtiv Mecarbil

Synthesis of Heterocycles

z1229
All PDFs of this category
1229
Copper-Catalyzed Synthesis of Di(het)arylamines
1230
Synthesis of Enaminones and Thiazoles Using Iodonium Ylides as Carbene Equivalents
1231
Cooperative Catalysis for the Asymmetric Synthesis of Piperidines
1232
Selective C-2 Directed-Carbonylation of Indoles and Pyrroles
1233
Synthesis of Substituted Morpholines by Fragmentation of Tetrazoles
1234
Rhodium-Catalyzed Synthesis of 2‑Arylindoles from N‑Aryl-2-aminopyridines
1235
Synthesis of Benzazepinones Involving an Unexpected Intramolecular Cyclization
1236
Electrocatalytic Synthesis of Imidazo[1,5-a]quinoline-3-carbonitriles
1237
Asymmetric Radical C–H Amination for the Synthesis of Azoles
1238
Three-Component Assembly of 3,4-Dihydroquinazolines
1239
Synthesis of Phosphinolines and Phosphepines
1240
Buchwald–Hartwig Coupling of Piperidines with Hetaryl Bromides
1241
Synthesis of 3-Phenylimidazo[1,2-a]pyridines by Annulation of Tetrazoles with Phenylacetylenes
1242
Copper-Catalyzed Cyclization of Enaminones to Polycyclic N-Fused Indoles
1243
An Illuminating Synthesis of Benzimidazoles

Synthesis of Materials and Unnatural Products

z1245
All PDFs of this category
1245
Developing a Dye for Lysosome
1246
Synthesis of a π-Conjugated Macrocyclic Oligofuran: The First of Many to Come
1247
peri-Disubstituted Naphthalimides via Decarboxylative Arylation
1248
Finally, Furfural Flourishes
1249
Unmasked ‘Click Chemistry’
1250
Proton Hole-in-One With TriQuinoline
1251
Synthesis of Carbon-Skeleton-Like Molecules
1252
Going Full Circle: From Linear to Cyclic pH-Responsive Water-Soluble Cyclic Polymer
1253
Aryl Sulfones and Aryl Boronic Acids Make a Nice Couple
1254
Ring-Opening Doors to Controlled Polymerization with Hydrogen-Bond-Driven Organocatalysis
1255
Stepwise Synthesis of an Axially Chiral 1,1′-Biazulene and its π-Extended Derivative
1256
Synthesis of Sumanene

Metals in Synthesis

z1257
All PDFs of this category
1257
Palladium-Catalyzed Synthesis of Carboxylic Acids
1258
Copper-Mediated Trifluoromethylation of Aryl Sulfonium Salts
1259
Asymmetric C–H Alkylation of Fluoroarenes with Alkenes via Nickel/NHC Catalysis
1260
C–H Acetoxylation of Carboxylic Acids
1261
Reductive Dicarbofunctionalization of Alkenes
1262
Zinc-Catalyzed Tandem Asymmetric Friedel–Crafts Alkylation/Michael Addition
1263
Hydroalkylation of Terminal Alkynes with Primary or Secondary Alkyl Iodides
1264
Synthesis of 2-Arylquinazolines via Visible-Light-Induced Benzylic C–H Functionalization
1265
Enantioselective Allylic Substitution with Nucleophiles in Aqueous Solution under Iridium Catalysis
1266
Catalytic Interrupted Click/Acylation Reactions
1267
Enantioselective Preparation of Chiral Diamines
1268
Base-Catalyzed Synthesis of Fully Substituted Silyl Enol Ethers
1269
Photoredox/Nickel-Catalyzed C(sp3)–C(sp3) Cross-Coupling
1270
Anti-Markovnikov Hydroamination and Hydroamidation of Allylic Alcohols through Iron Catalysis
1271
Rhodium(III)-Catalyzed C–H Activation/Carbene Insertion/Lossen Rearrangement Sequence
1272
Nickel-Catalyzed Asymmetric Reductive Heck Cyclization
1273
Heteroaryl Thioether Directing Group in Oxidative Heck and C–H Functionalization Reactions
1274
Enantioselective Benzylic Arylations
1275
Photoreduction of Arenes and Heteroarenes
1276
Decarbonylative Suzuki–Couplings of Amides
1277
Ruthenium-Catalyzed Cross-Coupling of Anilines
1278
Enantioselective Access to Tetrahydroquinoxalines through Relay Epoxide Opening/Amination of Alcohols
1279
Photocatalysis: Asymmetric Intramolecular HAT in Photoexcited Catalyst–Substrate Complex
1280
β-C(sp3)-Methylation of Alcohols
1281
Preparation of β-Aminoboronates
1282
Copper-Catalyzed Asymmetric Annulation of Carbenes to Access Enantioenriched 2,3-Dihydrobenzofurans
1283
Palladium-Catalyzed C(sp3)–H Bond Activation of Phenylacetaldehydes
1284
Palladium-Catalyzed Aerobic Oxidative C-H Arylation
1285
The Hiyama–Denmark Cross-Coupling

Polymer-Supported Synthesis

z1287
All PDFs of this category
1287
Zeolitic Imidazole Framework Encapsulated Copper Nanoparticles for Hydrogenation of Aldehydes
1288
Transfer Hydrogenation of Unsaturated Compounds by Co NPs Encapsulated in N-doped Graphene
1289
Copper-Catalyzed Oxidative Cyclization of Benzylamines with 1,3-Dicarbonyl Compounds
1290
Controlled Reduction of Nitroarenes to Azo Compounds with Iron–Nitrogen Co-Doped Mesoporous Carbon
1291
Rh-Catalyzed Asymmetric Arylation of α,β-Unsaturated Carbonyl Compounds, Nitroalkenes, or Imines
1292
Hybrid Palladium Catalyst for Suzuki–Miyaura and Heck Reactions
1293
Selective Deprotection of Benzyl Carbamates on Micellar Nickel–Palladium Nanoparticles in Water
1294
Ruthenium-Photocatalyzed Aerobic Oxidation of Benzylic Halides and Cyclization of Tertiary Anilines
1295
One-Pot Synthesis of 5-Substituted 1H-Tetrazoles on a Silica-Coated Fe3O4-Supported Copper(II) Complex
1296
Oxidative Synthesis of Nitriles from Primary Alcohols and Ammonia Catalyzed by Cobalt Nanoparticles
1297
Synthesis of Xanthene Derivatives by Using a Lewis Acidic Ionic Liquid Immobilized on Perlite NPs
1298
Cerium(IV) Oxide-Catalyzed Direct Phenolysis of Amides

Organo- and Biocatalysis

z1299
All PDFs of this category
1299
A Newly Designed Catalyst for Additive-Free Mitsunobu Reactions
1300
Brønsted Acid Catalyzed Asymmetric House–Meinwald Rearrangement of p-Hydroxyphenyl Epoxides
1301
Asymmetric Functionalization of C(sp3)–H Bonds in 2-Alkylindoles
1302
NHC-Catalyzed Carboacylation of Alkenes
1303
Lewis Base Catalyzed Enantioselective Sulfenoamination of Olefins
1304
Asymmetric NHC-Catalyzed Rauhut–Currier Reaction of Weakly Electrophilic Bisenoates
1305
Phosphenium Ion Catalyzed Enantioselective Reduction of Cyclic Imines
1306
Asymmetric Phosphoric Acid Catalyzed Multi-Component Synthesis of Axially Chiral N-Arylindoles
1307
N-Heterocyclic Carbene Catalyzed Stetter Reaction of Cyclic Enones
1308
Organometallic Organocatalysts

Chemistry in Medicine and Biology

z1309
All PDFs of this category
1309
Water-Soluble BODIPY Dyes for Voltage Imaging
1310
Pre-Exposure Prophylaxis (PrEP)
1311
Sign-Inversion in Photopharmacology
1312
HPLC-Free Synthesis of Nucleoside Triphosphates
1313
Targetable, Bright Small-Molecule Ca2+ Indicators
1314
Macrocycle Library Synthesis through Thiol-to-Amine Cyclization
1315
Membrane Probes for Super-Resolution Imaging of Plasma Membranes
1316
Activatable Photosensitizers for Photodynamic Therapy
1317
C–N Coupling of Aryl Thianthrenium Salts
1318
An Aromatic Brønsted Acid Catalyst for the Direct Glycosylation of Amides
1319
pH-Sensitive μ Opioid Receptor Agonists
1320
Conformational Restricted Cyclopropanated Nucleoside Derivatives
1321
SPiDER-Killer-βGal: A Photosensitizer for Targeted Cell Ablation with Single-Cell Resolution

Peptide Chemistry

z1323
All PDFs of this category
1323
Synthesis of Cyclic and Bicyclic Peptides
1324
Palladium-Catalyzed Conversion of Phenyl Aspartates into Ketones
1325
Ruthenium-Catalyzed C–H Alkylation of Resin-Attached Tryptophan
1326
Asymmetric Hydrogenation of β-Aminoacrylates to β-Amino Acid Derivatives
1327
Palladium-Catalyzed Acylation of Phenylalanine-Containing Peptides
1328
Palladium-Catalyzed Arylation of Sulfonamide-Containing Peptides
1329
Synthesis of Diazirines from Amino Acids by Using Phenyliodonium Diacetate
1330
Synthesis of Dehydroamino Acid Containing Peptides
1331
Synthesis of Benzotriazole-Derived α-Amino Acids
1332
Synthesis of Activated Amides and Directed C(sp3)–H Arylation
1333
Peptide Nanoassemblies Promote Enantioselective Hydrogenation

Flow Chemistry

z1335
All PDFs of this category
1335
Continuous Flow Electrochemical Oxidation of Alcohols
1336
Functionalized Alkyllithium Reagents Towards Heterotelechelic Polymers
1337
Radical-Based Late-Stage C−H 18F-Difluoromethylation of N-Heteroaromatics
1338
Organocatalyzed Photooxygenation of β-Dicarbonyl Compounds in Flow Photomicroreactors
1339
One-Step Synthesis of 2-Fluoroadenine in a Continuous Flow Operation