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Synlett 2008(14): 2093-2096  
DOI: 10.1055/s-2008-1078251
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

A Synthetic Approach to the Communesins

Jonathan H. George, Robert M. Adlington*
Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK
Fax: +44(1865)275632; e-Mail: robert.adlington@chem.ox.ac.uk;
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Publikationsverlauf

Received 30 May 2008
Publikationsdatum:
05. August 2008 (online)

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Abstract

A synthetic approach to the communesin family of ­indole alkaoids has been investigated, with a cascade reaction sequence involving formation of a transient 1-alkoxycarbonyl­imidazole intermediate and subsequent addition onto an indole as the key step.

Key words

alkaloids - indoles - cascade reactions - heterocycles - communesins

    References and Notes

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    Thieme Connect
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Crystal structure obtained for compound 20. CCDC 689636 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.