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DOI: 10.1055/s-2008-1072786
Enantiomerically Pure Cyclopropylamines via C-B to C-N Conversion
Publication History
Publication Date:
07 May 2008 (online)

Abstract
For the first time cyclopropyltrifluoroborates have been utilized to form cyclopropylamines in a one-pot procedure. The scope was not only demonstrated by successfully reacting various racemic cis- and trans-2-substituted cyclopropanes as well as azides, but also by applying the sequence to enantiomerically pure building blocks. An approach to tranylcypromine as well as belactosin A is outlined.
Key words
boron - cyclopropanes - asymmetric synthesis - cyclopropylamine
- Reviews:
- 1a
Salaün J. Top. Curr. Chem. 2000, 207: 1 - 1b
Wessjohann LA.Brandt W.Thiemann T. Chem. Rev. 2003, 103: 1625 ; see also ref. 13-16 - Reviews on cyclopropane chemistry:
- 2a
The Chemistry of the Cyclopropyl Group
Patai S.Rappoport Z. Wiley; New York: 1987. - 2b
Methods of Organic Synthesis (Houben-Weyl)
Vol. E17a-c:
de Meijere A. Thieme; Stuttgart: 1997. - 2c Thematic issue on cyclopropane chemistry (guest editor: de Meijere, A.): Chem. Rev. 2002, 103: 931
- Selected recent examples for the syntheses of aminocyclopropane derivatives:
- 2d
Beumer R.Bubert C.Cabrele C.Vielhauer O.Pietzsch M.Reiser O. J. Org. Chem. 2000, 65: 8960 - 2e
Adams LA.Aggarwal VK.Bonnert RV.Bressel B.Cox RJ.Shepherd J.de Vicente J.Walter M.Whittingham WG.Winn CL. J. Org. Chem. 2003, 68: 9433 - 2f
Wurz RP.Charette AB. J. Org. Chem. 2004, 69: 1262 - 2g
Bégis G.Sheppard TD.Cladingboel DE.Motherwell WB.Tocher DA. Synthesis 2005, 3186 - 2h
Moreau B.Charette AB. J. Am. Chem. Soc. 2005, 127: 18014 - 2i
Denolf B.Mangelinckx S.Törnroos KW.de Kimpe N. Org. Lett. 2007, 9: 187 - 3a
Chaplinski V.de Meijere A. Angew. Chem., Int. Ed. Engl. 1996, 35: 413 ; Angew. Chem. 1996, 108, 491 - 3b
de Meijere A.Kozhushkov SI.Savchenko AI. J. Organomet. Chem. 2004, 689: 2033 - 3c Recent review on a related approach:
Bertus P.Szymoniak J. Synlett 2007, 1346 - 4a
Kulinkovich OG.Sviridov SV.Vasilevskii DA.Pritytskaya TS. Russ. J. Org. Chem. 1989, 25: 2244 - 4b
Kulinkovich OG.de Meijere A. Chem. Rev. 2000, 100: 2789 - 5a
Pietruszka J.Witt A. J. Chem. Soc., Perkin Trans. 1 2000, 4293 - 5b
Luithle JEA.Pietruszka J. Eur. J. Org. Chem. 2000, 2557 - 5c
Luithle JEA.Pietruszka J. J. Org. Chem. 1999, 64: 8287 - 5d
Luithle JEA.Pietruszka J.Witt A. Chem. Commun. 1998, 2651 - 5e
Luithle JEA.Pietruszka J. Liebigs Ann./Recl. 1997, 2297 - 6a
Hohn E.Pietruszka J. Adv. Synth. Catal. 2004, 346: 863 - 6b
Pietruszka J.Witt A.Frey W. Eur. J. Org. Chem. 2003, 3219 - 6c
Garcia Garcia P.Hohn E.Pietruszka J. J. Organomet. Chem. 2003, 680: 281 - 6d
Luithle JEA.Pietruszka J. J. Org. Chem. 2000, 65: 9194 - 6e
Pietruszka J.Schöne N. Synthesis 2006, 24 - 6f
Pietruszka J.Schöne N. Eur. J. Org. Chem. 2004, 5011 - 6g
Pietruszka J.Schöne N. Angew. Chem. 2003, 115: 5796 - 7
Hohn E.Pietruszka J.Solduga G. Synlett 2006, 1531 - Selected early examples:
- 8a
Hildebrand JP.Marsden SP. Synlett 1996, 893 - 8b
Wang X.Deng M. J. Chem. Soc., Perkin Trans. 1 1996, 2663 - 8c
Charette AB.Giroux A. J. Org. Chem. 1996, 61: 8718 - 8d
Charette AB.Freitas-Gil RPD. Tetrahedron Lett. 1997, 38: 2809 - 8e
Pietruszka J.Widenmeyer M. Synlett 1997, 977 ; see also ref. 7 - Selected examples:
- 9a
Imai T.Mineta H.Nishida S. J. Org. Chem. 1990, 55: 4986 - 9b
Fontani P.Carboni B.Vaultier M.Maas G. Synthesis 1991, 605 - 9c
Pietruszka J.Rieche ACM.Wilhelm T.Witt A. Adv. Synth. Catal. 2003, 345: 1273 - 10a
Suzuki A.Sono S.Itoh M.Brown HC.Midland MM. J. Am. Chem. Soc. 1971, 93: 4329 - 10b
Brown HC.Midland MM.Levy AB. J. Am. Chem. Soc. 1973, 95: 2394 - 10c
Tamura Y.Minamikawa J.Fujii S.Ikeda M. Synthesis 1974, 196 - 10d
Kabalka GW.Sastry KAR.McCollum GW.Yoshioka H. J. Org. Chem. 1981, 46: 4296 - 10e
Kabalka GW.McCollum GW.Kunda SA. J. Org. Chem. 1984, 49: 1656 - 10f
Brown HC.Kim K.-W.Cole TE.Singaram B. J. Am. Chem. Soc. 1986, 108: 6761 - 10g
Carboni B.Vaultier M.Carrié R. Tetrahedron 1987, 43: 1799 - 10h
Kabalka GW.Goudgaon NM.Liang Y. Synth. Commun. 1988, 18: 1363 - 10i
Kabalka GW.Wang Z. Organometallics 1989, 8: 1093 - 10j
Kabalka GW.Wang Z. Synth. Commun. 1990, 20: 231 - 10k
Brown HC.Salunkhe AM.Singaram B. J. Org. Chem. 1991, 56: 1170 - 10l
Chavant P.-Y.Lhermitte F.Vaultier M. Synlett 1993, 519 - 10m
Phanstiel OIV.Wang QX.Powell DH.Ospina MP.Leeson BA. J. Org. Chem. 1999, 64: 803 - 10n
Ramachandran PV.Burghardt TE. Pure Appl. Chem. 2006, 78: 1397 - 11a
Fang G.-H.Yan Z.-J.Deng M.-Z. Org. Lett. 2004, 5: 357 - 11b Review on organotrifluoroborates, for example:
Darses S.Genet J.-P. Eur. J. Org. Chem. 2003, 4313 - 12a
Matteson DS.Kim GY. Org. Lett. 2002, 4: 2153 - 12b
Kim BJ.Matteson DS. Angew. Chem. Int. Ed. 2004, 43: 3056 ; Angew. Chem. 2004, 116, 3118 - 14a
Riley TN.Brier CG. J. Med. Chem. 1972, 5: 1187 - 14b
Smith DF. Pharmakopsychiat. 1980, 13: 130 - 14c
Arvidsson L.-E.Johansson AM.Hacksell U.Nilsson JLG.Svensson K.Hjorth S.Magnusson T.Carlsson A.Lindberg P.Andersson B.Sanchez D.Wirkström H.Sundell S. J. Med. Chem. 1988, 31: 92 - 14d
Csuk R.Schabel MJ.von Scholz Y. Tetrahedron: Asymmetry 1996, 7: 3505 - 15
Asai A.Hasegawa A.Ochiai K.Yamashita Y.Mizukami T. J. Antibiot. 2000, 53: 81 - 16a
Asai A,Mizukami T,Yamashita Y,Ikeda S, andKanada Y. inventors; EP 1166781. ; Chem. Abstr. 2002, 133, 120677 - 16b
Asai A.Tsujita T.Sharma SV.Yamashita Y.Akinaga S.Funakoshi M.Kobayashi H.Mizukami T. Biochem. Pharmacol. 2004, 67: 227 - 17a
Armstrong A.Scutt JN. Chem. Commun. 2004, 510 - 17b
Larionov OV.de Meijere A. Org. Lett. 2004, 6: 2153 - 17c
Yoshida K.Yamaguchi K.Arisawa M.Matsuda A.Shuto S. In Peptide ScienceIshida H.Mihara H. 2006. p.184
References and Notes
General Procedure for the C-B to C-N Conversion
Under an atmosphere of dry nitrogen, the trifluoroborate 3 (1 equiv) was suspended in a mixture of toluene (10 mL/mmol trifluoroborate 3) and MeCN (2.5 mL/mmol trifluoroborate 3). Then, SiCl4 (1 M in CH2Cl2, 2 equiv) was added at r.t. and stirred for 20 min. The corresponding azide 5 (1.4 equiv) was added and the reaction mixture was stirred at r.t. or 40 °C for 5-15
h (depending on the azide used). The reaction was quenched with H2O (10 mL/mmol trifluoroborate 3), and the layers were separated. The organic layer was extracted with HCl (1 M; 5
× 10 mL/mmol trifluoroborate 3). The combined aqueous layers were strongly basified with aq KOH (40%). The amine
was extracted with Et2O (4 × 50 mL/mmol trifluoroborate 3). The combined ether layers were dried over Na2CO3. The solvent was removed under reduced pressure.