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Synthesis 2008(10): 1607-1611
DOI: 10.1055/s-2008-1072575
DOI: 10.1055/s-2008-1072575
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes
Further Information
Received
28 January 2008
Publication Date:
07 April 2008 (online)
Publication History
Publication Date:
07 April 2008 (online)
Abstract
p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.
Key words
alkynes - annulations - isocoumarin - isochromene - microwave activation
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