Synthesis 2008(8): 1283-1287  
DOI: 10.1055/s-2008-1072517
PAPER
© Georg Thieme Verlag Stuttgart · New York

Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates

Jhillu S. Yadav*, Basi V. Subba Reddy, Ummareddy V. Subba Reddy, Darshanoju N. Chary
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27160512.; e-Mail: yadav@iict.res.in;
Further Information

Publication History

Received 9 January 2008
Publication Date:
18 March 2008 (online)

Abstract

A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce α-oxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient, and practical.