Synthesis of Bis(aminofuryl)bicinchoninic
Amides by a One-Pot Three-Component Reaction of Isocyanides,
Acetylenic Esters, and Bicinchoninic Acid

Abdolali Alizadeh; Qasem Oskueyan; Sadegh Rostamnia; Abbass Ghanbari-Niaki; Ali Rreza Mohebbi

doi:10.1055/s-2008-1067246

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Synthesis 2008(18): 2929-2932
DOI: 10.1055/s-2008-1067246

PAPER

Synthesis of Bis(aminofuryl)bicinchoninic Amides by a One-Pot Three-Component Reaction of Isocyanides, Acetylenic Esters, and Bicinchoninic Acid

Abdolali Alizadeh*^a, Qasem Oskueyan^a, Sadegh Rostamnia^a, Abbass Ghanbari-Niaki^b, Ali Rreza Mohebbi^c
^a Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran
^b Department of Physical Education & Sports Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran
^c Otto-Diels-Institut für Organische Chemie, Christian-Albrechts University of Kiel, 24098 Kiel, Germany
Fax: +98(21)88006544; e-Mail: abdol_alizad@yahoo.com; e-Mail: aalizadeh@modares.ac.ir;

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Publication History

Received 9 May 2008
Publication Date:
22 August 2008 (online)

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Abstract

A simple synthesis of dialkyl 2-(alkylamino)-5-[alkyl({2-[4-({alkyl[5-(alkylamino)-3,4-bis(alkoxycarbonyl)-2-furyl]amino}carbonyl)-2-quinolyl]-4-quinolyl}carbonyl)amino]-3,4-furandicarboxylate derivatives is described. This involves reaction of isocyanides, dialkyl acetylenedicarboxylates, and bicinchoninic acid (BCA) in MeCN-THF at 25 ˚C for 36 hours.

Key words

dialkyl acetylenedicarboxylate - isocyanide - bicinchoninic acid - multicomponent reaction - bicinchoninic amide

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