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Synthesis 2008(18): 2933-2938
DOI: 10.1055/s-2008-1067219
DOI: 10.1055/s-2008-1067219
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkThe Stereoselective Synthesis of the C6-C18 Fragment of Scytophycin C Employing a Novel Synthetic Methodology
Weitere Informationen
Received
13 May 2008
Publikationsdatum:
11. August 2008 (online)
Publikationsverlauf
Publikationsdatum:
11. August 2008 (online)

Abstract
A novel synthetic approach towards the stereoselective synthesis of the C6-C18 fragment of the biologically active antitumor agent scytophycin C is described. The synthesis involves Marouka allylation, base-catalyzed intramolecular conjugate addition, Wittig olefination, and a tandem allylation.
Key words
scytophycin - allylation - olefination - trans-2,6-disubstituted dihydropyran
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References
Scytophycins isolated from other species of Scytonema and Cylindrospermum musicola see: refs. 3b and 3c.