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Synthesis 2008(17): 2683-2685  
DOI: 10.1055/s-2008-1067202
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Diethyl Chlorophosphate: A Mild and Versatile Reagent for the One-Pot Preparation of Isothiocyanates from Amines

Babak Kaboudin*, Ehsan Jafari
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran
Fax: +98(241)4214949; e-Mail: kaboudin@iasbs.ac.ir;
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Publikationsverlauf

Received 28 April 2008
Publikationsdatum:
24. Juli 2008 (online)

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Abstract

A simple, efficient, and new method has been developed for the synthesis of isothiocyanates from amines. The reaction of a variety of aromatic and aliphatic amines with carbon disulfide in the presence of diethyl chlorophosphate as an efficient reagent proceeded effectively to afford the corresponding isothiocyanates in moderate yields. This method is easy, rapid, and moderate-yielding for the synthesis of isothiocyanates from amines.

Key words

isothiocyanates - amines - diethyl chlorophosphate - phosphoroamidates

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