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Synthesis 2008(18): 2996-3008  
DOI: 10.1055/s-2008-1067198
FEATUREARTICLE
© Georg Thieme Verlag Stuttgart ˙ New York

Generation and Intermolecular Additions of Pyridylmethyl Radicals

Zorana Ferjancic, Béatrice Quiclet-Sire, Samir Z. Zard*
Laboratoire de Synthèse Organique associé, CNRS Ecole Polytechnique, 91128 Palaiseau, France
Fax: +33(1)69335972; e-Mail: zard@poly.polytechnique.fr;
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Publication History

Received 29 March 2008
Publication Date:
24 July 2008 (online)

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Abstract

2-, 3-, or 4-Pyridylmethyl radicals can be made to add to nonactivated alkenes to give a variety of otherwise inaccessible pyridine derivatives. Bicyclic structures can be obtained by combining the radical addition with ionic ring-closure steps.

Key words

radical additions - heterocycles - pyridines - alkenes - cyclization­

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