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Synthesis 2008(15): 2347-2352  
DOI: 10.1055/s-2008-1067160
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Pd(OAc)2-Catalyzed Aminocarbonylation of Aryl Iodides with Aromatic or Aliphatic Amines in Water

Pawan J. Tambade, Yogesh P. Patil, Mayur J. Bhanushali, Bhalchandra M. Bhanage*
Department of Chemistry, Institute of Chemical Technology (Autonomous), University of Mumbai, N. Parekh Marg, Matunga, Mumbai 400019, India
Fax: +91(22)24145614; e-Mail: bhalchandra_bhanage@yahoo.com;
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Publication History

Received 31 March 2008
Publication Date:
08 July 2008 (online)

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Abstract

An efficient ligand-free protocol has been developed for the amincocarbonylation of aryl iodides with aromatic/aliphatic amines using palladium(II) acetate as a catalyst in water under milder operating conditions. The system tolerated a wide variety of hindered and functionalized aryl iodides/amines and afforded the desired amides in excellent yields at low catalyst concentration.

Key words

carbonylation - aryl iodides - amines - amides - palladium

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