Facile and Straightforward Method Leading to Substituted 4-Amino-1-arylpyrazoles

Petr Šimůnek; Markéta Svobodová; Valerio Bertolasi; Vladimír Macháček

doi:10.1055/s-2008-1067042

PAPER

Facile and Straightforward Method Leading to Substituted 4-Amino-1-arylpyrazoles

Petr Šimůnek*^a, Markéta Svobodová^a, Valerio Bertolasi^b, Vladimír Macháček^a
^a Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, Nám. Čs. Legií 565, 53210 Pardubice, Czech Republic
Fax: +420(466)037068; e-Mail: petr.simunek@upce.cz;
^b Dipartimento di Chimica and Centro di Strutturistica Diffrattometrica, Università di Ferrara, Via L. Borsari 46, 44100 Ferrara, Italy

Abstract

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Abstract

A new method for the synthesis of substituted 4-amino-1-arylpyrazoles is described, starting from β-enaminones and variously substituted benzenediazonium tetrafluoroborates. The reaction proceeds under mild conditions, is very simple to perform, and is applicable to a relatively wide range of substituents, both at the β-enaminone and diazonium salt starting materials.

Key words

diketones - enaminones - diazonium salts - pyrazoles - heterocycles

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