Abstract
Purpose: Aim of this study was to evaluate the dynamic changes in renal relative signal intensity
(RSI) following the administration of Gd-DTPA in adolescent pigs with complete and
partial unilateral ureteric obstruction. Methods: Pigs were divided into 3 groups: partial and complete unilateral ureteric obstruction
and controls. Complete unilateral ureteric obstruction (CUUO) was created by ligating
the left ureter, whereas partial unilateral ureteric obstruction (PUUO) was created
in pigs of 2 weeks of age by embedding the left ureter into the psoas muscle. Dynamic
MRI was performed before and at 0 – 60 min after an intravenous bolus injection of
Gd-DTPA. Mean RSI of the renal cortex, medulla and pelvis was measured and interpreted
as an indirect measure of the renal function. In addition, renography was performed,
and renal morphology was examined in vitro. Results: Three phases of RSI were identified. The dynamic RSI patterns differed markedly between
obstructed and control kidneys. In PUUO kidneys, Phase 1 of the mean RSI of the cortex
and medulla demonstrated a decreased amplitude and prolonged duration, whereas in
Phase 2 the mean RSI of the pelvis was increased. In acute CUUO kidneys, the mean
RSI patterns were similar to those of controls, except for a significant increase
of the pelvic mean RSI. Conclusions: Gd-DTPA enhanced dynamic MRI allowed a characterization and differentiation of renal
function and morphology of normal and obstructed kidneys, and secondly, provided potentially
important information on renal concentrative and filtration availability.
Key words
ureteric obstruction - MRI - Gd‐DTPA - swine
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Prof. M.D., Ph.D. Jian Guo Wen
Department of Pediatric Surgery
Urodynamic Center of First Affiliated Hospital of Zhengzhou University
No. 1 Jianshe East Road
Zhengzhou City 450052
China
eMail: jgwen@zzu.edu.cn
