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Synthesis 2008(6): 865-870  
DOI: 10.1055/s-2008-1032191
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Carbohydrate-Conjugated Furo[2,3-d]pyrimidine by ‘Click Chemistry’

Xuanye Jina, Haixin Dingb, Ruchun Yangb, Qiang Xiao*b, Yong Ju*a
a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China
Fax: +86(10)62781695; e-Mail: juyong@tsinghua.edu.cn;
b Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, P. R. of China
Fax: +86(791)3826894; e-Mail: qxiao75@yahoo.com.cn;
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Publication History

Received 5 November 2007
Publication Date:
28 February 2008 (online)

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Abstract

Compounds belonging to a new type of furo[2,3-d]pyrimidine nucleoside conjugated with carbohydrate were synthesized by Sonogashira coupling and ‘click chemistry’. Their structures were confirmed on the basis of various types of spectroscopy.

Key words

Sonogashira coupling - click chemistry - nucleosides - heterocycles - carbohydrates