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Synthesis 2008(6): 985-989
DOI: 10.1055/s-2008-1032190
DOI: 10.1055/s-2008-1032190
PAPER
© Georg Thieme Verlag Stuttgart · New York
A New Versatile Synthesis of 2,5-Disubstituted 3-(Methylsulfanyl)thiophenes
Further Information
Received
3 December 2007
Publication Date:
28 February 2008 (online)
Publication History
Publication Date:
28 February 2008 (online)
Abstract
A one-pot regioselective functionalization of 3-(methylsulfanyl)thiophene with different electrophiles at the 2- and 5-positions is reported. Proper selection of the experimental conditions allows the preparation of polysubstituted products not otherwise easily available.
Key words
thiophene - regioselectivity - metalations - lithiation - carbanions
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