A New Versatile Synthesis of 2,5-Disubstituted 3-(Methylsulfanyl)thiophenes

Abstract

A one-pot regioselective functionalization of 3-(methylsulfanyl)thiophene with different electrophiles at the 2- and 5-positions is reported. Proper selection of the experimental conditions allows the preparation of polysubstituted products not otherwise easily available.

Key words

thiophene - regioselectivity - metalations - lithiation - carbanions­

References

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