The sequential homoaldol-lactonization-alkylation/acylation reactions of ethyl pyruvate
with a variety of halides were achieved by using DBU along with Et3N as the base. The protocol provides an expedient one-pot synthesis of O-protected
isotetronic acid derivatives. The high-yielding synthesis of an unprotected isotetronic
acid is also described.
pyruvate - aldol reactions - one-pot reactions - isotetronic acids