Literatur
- 1 Aptivus. Prescribing Information. Boehringer Ingelheim International GmbH Ingelheim,
Germany 10 003 515/US/1, Issued June 23 2005
- 2 Department of Health and Human Services .Guidelines for the Use of Antiretroviral
Agents in HIV-1-Infected Adults and Adolescents - October 10, 2006, updated February
2007. www.aidsinfo.nih.gov, accessed 13 052007
- 3 Department of Health and Human Services .Recommendations for Use of Antiretroviral
Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce
Perinatal HIV-1 Transmission in the United States July 6, 2006. www.aidsinfo.nih.gov,
assessed Sept 2006
- 4 http://medicine.iupui.edu/flockhart/table.htm. accessed. 10.11.2006
- 5
Back D, Gibbons S, Khoo S.
An update on therapeutic drug monitoring for antiretroviral drugs.
Ther Drug Monit.
2006;
28
468-473
- 6
Boffito M, Kurowski M, Kruse G, Hill A, Benzie A, Nelson M, Moyle G, Gazzard B, Pozniak A.
Atazanavir enhances saquinavir hard-gel concentrations in a ritonavir boosted once-daily
regimen.
AIDS.
2004;
18
1291-1297
- 7
Bossi P, Peytavin G, Ait-Mohand H. et al .
GENOPHAR: a randomized study of plasma drug measurements in association with genotypic
resistance testing and expert advice to optimize therapy in patients failing antiretroviral
therapy.
HIV Med.
2004;
5
352-359
- 8
Breilh D, Pellegrin I, Rouzes A. et al .
Virological, intracellular and plasma pharmacological parameters predicting response
to lopinavir/ritonavir (KALEPHAR study).
AIDS.
2004;
18
1305-1310
- 9
Brundage R C, Yong Y H, Fenton T, Spector S A, Starr S E, Fletcher C V.
Intrapatient variability of efavirenz concentrations as a predictor of virologicresponse
to antiretroviral therapy.
Antimicrob Agents Chemother.
2004;
48
979-984
- 10
Burger D, Hugen P, Reiss P. et al .
Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected
individuals.
AIDS.
2003;
17
1157-1165
- 11
Burger D, van Rossum A, Hugen P. et al .
Pharmacokinetics of the protease inhibitor indinavir in human immunodeficiency virus
type 1-infected children.
Antimicrob Agents Chemother.
2001;
45
701-705
- 12 Sustiva product information. Bristol Myers Squibb Princeton, 08543 NJ, USA T4-B0001
- 04 - 05/Revised, issued 2005
- 13
Crommentuyn K, Scherpbier H, Kuijpers T, Mathot R, Huitema A, Beijnen J.
Population pharmacokinetics and pharmacodynamics of nelfinavir and its active metabolite
M8 in HIV-1-infected children.
Pediatr Infect Dis J.
2006;
25
538-543
- 14
Eron J, Feinberg J, Kessler H. et al .
Once-daily versus twice-daily lopinavir/ritonavir in antiretroviral-naïve HIV-positive
patients: a 48-week randomized clinical trial.
J Infect Dis.
2004;
189
265-272
- 15
Fang C T, Chang Y Y, Hsu H M. et al .
Life expectancy of patients with newly-diagnosed HIV infection in the era of highly
active antiretroviral therapy.
Qjm.
2007;
100
97-105
- 16
Fellay J, Marzolini C, Meaden E, Back D, Buclin T, Chave J. et al .
Response to antiretroviral treatment in HIV-1 infected individuals with allelic variants
of the multidrug resistance transporter 1.
Lancet.
2002;
359
30-36
- 17
Fletcher C, Anderson P, Kakuda T, Schacker T, Henry K, Gross C, Brundage R.
Concentration-controlled compared with conventional antiretroviral therapy for HIV
infection.
AIDS.
2002;
16
551-560
- 18
de Gonzalez R equena DBS, Garazzino S, Sciandra M. et al .
Nevirapine plasma exposure affects both durability of viral suppression and selection
of nevirapine primary resistance mutations in a clinical setting.
Antimicrob Agents Chemother.
2005;
49
3966-3969
- 19
Haas D W, Smeaton L M, Shafer R W. et al .
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz
and/or Nelfinavir.
J Infect Dis.
2005;
192
1931-1942
- 20
Hayashi S, Beckerman K, Homma M, Kosel B, Aweeka F.
Pharmacokinetics of indinavir in HIV-positive pregnant women.
AIDS.
2000;
14
1061-1062
- 21
Hirt D, Treluyer J, Jullien V. et al .
Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with
133 women.
Antimicrob Agents Chemother.
2006a;
50
2079-2086
- 22
Hirt D, Urien S, Jullien V. et al .
Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with
182 children.
Antimicrob Agents Chemother.
2006b;
50
910-916
- 23
Huang Y, Liu D, Wu H.
Hierarchical Bayesian methods for estimation of parameters in a longitudinal HIV dynamic
system.
Biometrics.
2006;
62
413-423
- 24
Johnson M, Gathe J J, Podzamczer D. et al .
A Once-Daily Lopinavir/Ritonavir-Based Regimen Provides Noninferior Antiviral Activity
Compared With a Twice-Daily Regimen.
J Acquir Immune Defic Syndr.
2006; [Epub ahead of print];
- 25
Johnson M, Grinsztejn, B, Rodriguez C. et al .
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing
multiple virological failures.
AIDS.
2005;
19
685-694
- 26
Kappelhoff B S, van Leth F, MacGregor T R, Lange J, Beijnen J H, Huitema A D.
Nevirapine and efavirenz pharmacokinetics and covariate analysis in the 2NN study.
Antivir Ther.
2005;
10
145-155
- 27
Kashuba A.
Drug-drug interactions and the pharmacotherapy of HIV infection.
Top HIV Med.
2005;
13
64-69
- 28
Kosel B, Beckerman K, Hayashi S, Homma M, Aweeka F.
Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women.
AIDS.
2003;
17
1195-1199
- 29
la P orte C, Back D, Blaschke T. et al .
Updated guidelines to perform therapeutic drug monitoring for antiretroviral agents.
Reviews in Antiviral Therapy.
2006;
3
3-14
- 30
Lima V D, Hogg R S, Harrigan P R. et al .
Continued improvement in survival among HIV-infected individuals with newer forms
of highly active antiretroviral therapy.
AIDS.
2007;
21
685-692
- 31
Marzolini C TA, Decosterd L A, Greub G, Biollaz J, Buclin T.
Efavirenz plasma levels can predict treatment failure and central nervous system side
effects in HIV-1-infected patients.
AIDS.
2001;
15
71-75
- 32
Mirochnick M, Capparelli E.
Pharmacokinetics of antiretrovirals in pregnant women.
Clin Pharmacokinet.
2004;
43
1071-1087
- 33
Ren Y, Nuttall J, Egbers C. et al .
High prevalence of subtherapeutic plasma concentrations of efavirenz in children.
J Acquir Immune Defic Syndr.
2007;
45
133-136
- 34
Rodriguez-Novoa S, Martin-Carbonero L, Barreiro P. et al .
Genetic factors influencing atazanavir plasma concentrations and the risk of severe
hyperbilirubinemia.
AIDS.
2007;
21
41-46
- 35
Rosso R, Di Biagio A, Dentone C. et al .
Lopinavir/ritonavir exposure in treatment-naive HIV-infected children following twice
or once daily administration.
J Antimicrob Chemother.
2006;
57
1168-1171
- 36
Sension M G.
Long-Term suppression of HIV infection: benefits and limitations of current treatment
options.
J Assoc Nurses AIDS Care.
2007;
18
S2-10
- 37
Stek A M, Mirochnick M, Capparelli E. et al .
Reduced lopinavir exposure during pregnancy.
AIDS.
2006;
20
1931-1939
- 38
Verweel G, Burger D M, Sheehan N L. et al .
Plasma concentrations of the HIV-protease inhibitor lopinavir are suboptimal in children
aged 2 years and below.
Antivir Ther.
2007;
12
453-458
- 39
von Hentig N, Babacan E, Staszewski S, Stürmer M, Doerr H, Lötsch J.
Predictive factors for response to a boosted dual HIV-protease inhibitor therapy with
saquinavir and lopinavir in extensively pretreated patients in clinical practice.
Antivir Ther.
2007a;
12
1237-46
- 40
von Hentig N, Carlebach A, Gute P. et al .
A comparison of the steady-state pharmacokinetics of nevirapine in men, nonpregnant
women and women in late pregnancy.
Br J Clin Pharmacol.
2006a;
62
552-559
- 41
von Hentig N, Carlebach A, Gute P. et al .
A comparison of the steady-state pharmacokinetics of nevirapine in men, nonpregnant
women and women in late pregnancy.
Br J Clin Pharmacol.
2006b;
62
552-559
- 42
von Hentig N, Koenigs C, Elanjikal S. et al .
Need for therapeutic drug monitoring in HIV-1 infected children receiving efavirenz
doses according to international guidelines.
Eur J Med Res.
2006c;
11
377-380
- 43
von Hentig N, Muller A, Rottmann C. et al .
Pharmacokinetics and tolerability of a combination of indinavir, lopinavir and ritonavir
in multiply pretreated HIV-1 infected adults.
Eur J Med Res.
2006d;
11
236-244
- 44
von Hentig N, Muller A, Rottmann C. et al .
Pharmacokinetics of saquinavir, atazanavir and ritonavir in a boosted double-protease
inhibitor twice-daily regimen.
Antimicrobial Agents and Chemotherapy.
2006d; accepted 12.12.2006;
- 45
von Hentig N, Muller A, Rottmann C. et al .
Pharmacokinetics of saquinavir, atazanavir, and ritonavir in a twice-daily boosted
double-protease inhibitor regimen.
Antimicrob Agents Chemother.
2007b;
51
1431-1439
- 46
Zhang X, Lin T, Bertasso A. et al .
Population pharmacokinetics of enfuvirtide in HIV-1-infected pediatric patients over
48 weeks of treatment.
J Clin Pharmacol.
2007;
47
510-517
Dr. med. Nils von Hentig
Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Johann Wolfgang
Goethe-Universität Frankfurt am Main
Theodor-Stern-Kai 7
60590 Frankfurt am Main
Phone: 069/63016956,
Fax: 069/63017636
Email: Hentig@em.uni-frankfurt.de