Am J Perinatol 1988; 5(4): 368-373
DOI: 10.1055/s-2007-999724
ORIGINAL ARTICLE

© 1988 by Thieme Medical Publishers, Inc.

Periconceptional Metabolic Status and Risk for Spontaneous Abortion in Insulin-Dependent Diabetic Pregnancies

Menachem Miodovnik, Francis Mimouni, Tariq A. Siddiqi, Reginald C. Tsang
  • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and Division of Neonatology, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio
Further Information

Publication History

Publication Date:
04 March 2008 (online)

ABSTRACT

The rate of clinically apparent spontaneous abortions in insulin-dependent diabetic pregnancies has been prospectively determined to be twice as frequent as for the general population (29.5% versus 10 to 15%). In a series of several successive studies, we have shown that spontaneous abortions are associated with poor metabolic control around conception and/or in the early weeks of pregnancy, but not in the 1 to 2 weeks preceding the abortive event itself. There is also a significant relationship between decreased maternal magnesium status (as assessed by maternal serum magnesium concentration) and adverse fetal outcome (spontaneous abortion and/or major congenital malformations) in insulin-dependent diabetic women. We speculate that improvement of glycemic control and of magnesium status before conception and in the very early phases of organogenesis might improve embryonic and fetal survival.

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